Nanobody (Nb) is the smallest natural antigen-specific binding functional fragment of about 12~15 kb (Figure 2D). The molecular weight of Nb is smaller than the monoclonal antibody mAb (~150 kb), Fab fragment (~55 kb) or HcAb (~90 kb) Figure 1A–C. Former study showed that these nanobodies can be genetically engineered from the heavy-chain antibody derived from camelids […]
Category Archives: Biologics
The globalization of the world’s economies, accompanied by increasing international travel, changing climates, altered human behaviour and demographics is leading to the emergence of different viral diseases, many of which are highly pathogenic and hence are considered of great public and animal health importance. To undertake basic research and therapeutic development, many of these viruses […]
Monoclonal antibodies (mAbs) against bacterial infections are more effective way to treat the antibiotic resistant strains. The antibacterial mAbs have several advantages such as reducing the antibiotic toxicity, treatment time and disease complications. there are numerous mAb products are under development for a range of infectious diseases. Currently, GeneMedi offers mAbs against gram negative bacteria, […]
Clostridium difficile continues to be one of the most prevalent hospital-acquired bacterial infections in the developed world. Alternative approaches under investigation to combat the anaerobic Gram-positive bacteria include fecal transplantation therapy, vaccines, and antibody-based immunotherapies. Inhibitory antibodies that recognize the primary C. difficilevirulence factors, toxin A and toxin B, are the most popular passive immunotherapies under investigation. […]
Rat-mouse hybrid IgG is a monoclonal antibody with binding sites for two different antigens, typically CD3 and a tumor antigen, making it a type of bispecific monoclonal antibody. In addition, its intact Fc-part can bind to an fc receptor on accessory cells like conventional monospecific antibodies. The net effect is that this type of drug […]
Full product list of Fc receptor (FcR) and immunoglobulin GeneMedi provides various Fc receptor (FcR), including FcγRI (CD64), FcγRIIA (CD32a), FcγRIIB (CD32b), FcγRIIC (CD32c), FcγRIIIA (CD16a), FcγRIIIB (CD16b), FcγRIII(CD16), FcγRIV, FcRn, TRIM21, FcRL1, FcRL4, FcRL5, FcαRI (CD89), PolyIgR, Fcα/uR (CD351), FcuR, FcεRI, FcεRII (CD23) in human, Cynomolgus/ Rhesus macaque, or mouse. Historically, these receptors have […]
The basic engineering procedure for a VLP construction consists of three main steps: (A) cloning and expression of VLP in the expression system, (B) purification of VLP, and (C) formulation. The first step in VLP production is to clone the viral structural genes of interest and expressed in different expression systems including, prokaryotic (bacteria, yeast) […]
Virus-like particles (VLPs) are highly structured protein complexes that resemble a native virus capsid ranging 20–800 nm. It is made up of one or more different molecules with the ability to self-assemble and mimicking the form and size of a virus devoid of viral genome and are therefore non-infectious. VLPs in general can be either enveloped […]
Bridge of 2 cells (engagers) By binding with 2 antigens from 2 different cells, the BsAbs can physically link them together, thus these kinds of BsAbs are named “engagers”. The redirecting of immune cells to tumor cells by the engagers makes the immune cell activated and then eliminate the target cells. The T cell engagers […]
Formats of bispecific antibodies (BsAbs) Many formats have been developed for BsAb generation as listed in the following table. Pipeline and MOA (mechanism of action) of bispecific antibodies (BsAbs) Bridge of 2 cells (engagers) By binding with 2 antigens from 2 different cells, the BsAbs can physically link them together, thus these kinds of BsAbs […]
