GM VLPxTM?Virus-like particles development platform

SOCAIL MEDIA

The basic engineering procedure for a VLP construction consists of three main steps: (A) cloning and expression of VLP in the expression system, (B) purification of VLP, and (C) formulation. The first step in VLP production is to clone the viral structural genes of interest and expressed in different expression systems including, prokaryotic (bacteria, yeast) or eukaryotic (baculovirus/insect cell, mammalian cell and plant). To obtain an intact VLPs it could be purified using ultracentrifugation and ion exchange chromatography. Finally, it will be formulated for biomedical application.

Fig. 1. Overview of VLP-platform
Fig. 1. Overview of VLP-platform