Diagnostic antibodies and antigens for Neurodegenerative diseases testing: Phospho-tau181 (p-tau181), Phospho-tau217 (p-tau217), tau proteins (Tau), neurofilament light chain (NFL), neurofilament protein (AD7c-NTP)

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Neurodegenerative diseases refer to the injury or dysfunction of one or more nerves, which results in numbness, tingling, muscle weakness and discomfort in the nerves affected part. Alzheimer’s disease (AD) is a progressive neurodegenerative disease most often characterized by initial memory impairment and cognitive decline that can ultimately affect behavior, speech, visuospatial orientation and the motor system, and it is the most common form of dementia. Peripheral neuropathy refers the injury or dysfunction of the peripheral nerves. Peripheral neuropathy might be acute or chronic, and sometimes it is reversible. Biochemical markers are increasingly used for the early diagnosis of the neuropathy. In addition, such markers may provide additional information for understanding the pathology of disease. Several markers such as a Phospho-tau181 (p-tau181), Phospho-tau217 (p-tau217), Phospho-tau231 (p-tau231), tau proteins (Tau), neurofilament light chain (NFL), Glial fibrillary acid protein (GFAP), beta-amyloid 42 (Aβ42), beta-amyloid 40 (Aβ40), AD-associated neuaronal thread protein (AD7c-NTP) and so on have been identified to be associated with the neurodegenerative diseases. Evidence has shown plasma biomarkers (p-tau181, p-tau217, p-tau231, GFAP, NfL and Aβ42/40) were significantly changed in preclinical Alzheimer Disease (AD). Detecting the quantity of these marker proteins from different samples may benefit from ELISA, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT.

Evidence has shown plasma biomarkers (p-tau181, p-tau217, p-tau231, GFAP, NfL, and Aβ42/40) were significantly changed in preclinical Alzheimer’s Disease (AD). Recently, our R&D department demonstrated that our GMP-h-p-tau217-Ab01 has a large linear range and good sensitivity against the GMP-h-p-tau217-Ag01. Below is the result of GeneMedi’s GMP-h-p-tau217-Ab01 (Anti-human p-tau217 antibody) validation with GMP-h-p-tau217-Ag01 (p-tau217 antigen) in ELISA. We highly recommend the Ab&Ag to you.

Figure 1. GeneMedi's GMP-h-p-tau217-Ab01 (Anti-human p-tau217 antibody) is validated to detect the GMP-h-p-tau217-Ag01 (p-tau217 antigen) in ELISA. EC50 = 25.85ng/ml.

Phospho-tau181 (p-tau181)

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GMP-h-p-tau181-Ag01:Recombinant Human p-tau181 Protein
Phospho-tau181 (p-tau181) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in p-tau181 level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation
GMP-h-p-tau181-Ab01,GMP-h-p-tau181-Ab02:Anti-Human p-tau181 mouse monoclonal antibody (mAb)
Human Phospho-tau181 (p-tau181) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other Phospho-tau181 (p-tau181) antibodies in p-tau181 level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation.

Phospho-tau217 (p-tau217)

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GMP-h-p-tau217-Ag01:Recombinant Human p-tau217 Protein
Phospho-tau217 (p-tau217) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in p-tau217 level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation
GMP-h-p-tau217-Ab01,GMP-h-p-tau217-Ab02:Anti-Human p-tau217 mouse monoclonal antibody (mAb)
Human Phospho-tau217 (p-tau217) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other Phospho-tau217 (p-tau217) antibodies in p-tau217 level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation.

Phospho-tau231 (p-tau231)

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Alzheimer Disease(AD)
GMP-h-p-tau231-Ag01
Phospho-tau231 (p-tau231) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in p-tau231 level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation
GMP-h-p-tau231-Ab01,GMP-h-p-tau231-Ab02
Human Phospho-tau231 (p-tau231) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other Phospho-tau231 (p-tau231) antibodies in p-tau231 level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation.
Human

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Alzheimer Disease(AD)
GMP-h-p-tau231-Ag01
Phospho-tau231 (p-tau231) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in p-tau231 level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation
GMP-h-p-tau231-Ab01,GMP-h-p-tau231-Ab02
Human Phospho-tau231 (p-tau231) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other Phospho-tau231 (p-tau231) antibodies in p-tau231 level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation.

tau proteins (Tau)

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Alzheimer Disease(AD)
GMP-h-Tau-Ag01
tau proteins (Tau) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Tau level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation
GMP-h-Tau-Ab01,GMP-h-Tau-Ab02
Human tau proteins (Tau) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other tau proteins (Tau) antibodies in Tau level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation.
Human

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Alzheimer Disease(AD)
GMP-h-Tau-Ag01
tau proteins (Tau) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Tau level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation
GMP-h-Tau-Ab01,GMP-h-Tau-Ab02
Human tau proteins (Tau) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other tau proteins (Tau) antibodies in Tau level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation.

neurofilament light chain (NFL)

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GMP-h-NFL-Ag01:Recombinant Human NFL Protein
neurofilament light chain (NFL) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in NFL level test of Neurodegenerative diseases (neurodegenerative diseases) and related syndrome evaluation
GMP-h-NFL-Ab01,GMP-h-NFL-Ab02:Anti-Human NFL mouse monoclonal antibody (mAb)
Human neurofilament light chain (NFL) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other neurofilament light chain (NFL) antibodies in NFL level test of Neurodegenerative diseases (neurodegenerative diseases) and related syndrome evaluation.

Glial fibrillary acid protein (GFAP)

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Alzheimer Disease(AD)
GMP-h-GFAP-Ag01
Glial fibrillary acid protein (GFAP) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in GFAP level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation
GMP-h-GFAP-Ab01,GMP-h-GFAP-Ab02
Human Glial fibrillary acid protein (GFAP) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other Glial fibrillary acid protein (GFAP) antibodies in GFAP level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation.

beta-amyloid 42 (Aβ42)

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Alzheimer Disease(AD)
GMP-h-Aβ42-Ag01
beta-amyloid 42 (Aβ42) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Aβ42 level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation
GMP-h-Aβ42-Ab01,GMP-h-Aβ42-Ab02
Human beta-amyloid 42 (Aβ42) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other beta-amyloid 42 (Aβ42) antibodies in Aβ42 level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation.

beta-amyloid 40 (Aβ40)

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Alzheimer Disease(AD)
GMP-h-Aβ40-Ag01
beta-amyloid 40 (Aβ40) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Aβ40 level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation
GMP-h-Aβ40-Ab01,GMP-h-Aβ40-Ab02
Human beta-amyloid 40 (Aβ40) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other beta-amyloid 40 (Aβ40) antibodies in Aβ40 level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation.

albumin protein (albumin)

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Alzheimer Disease(AD)
GMP-h-albumin-Ag01
albumin protein (albumin) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in albumin level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation
GMP-h-albumin-Ab01,GMP-h-albumin-Ab02
Human albumin protein (albumin) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other albumin protein (albumin) antibodies in albumin level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation.

beta-amyloid 38 (Aβ38)

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Alzheimer Disease(AD)
GMP-h-Aβ38-Ag01
beta-amyloid 38 (Aβ38) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Aβ38 level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation
GMP-h-Aβ38-Ab01,GMP-h-Aβ38-Ab02
Human beta-amyloid 38 (Aβ38) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other beta-amyloid 38 (Aβ38) antibodies in Aβ38 level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation.

Heart fatty acid-binding protein (HFABP)

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Alzheimer Disease(AD)
GMP-h-Aβ38-Ag01
beta-amyloid 38 (Aβ38) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Aβ38 level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation
GMP-h-Aβ38-Ab01,GMP-h-Aβ38-Ab02
Human beta-amyloid 38 (Aβ38) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other beta-amyloid 38 (Aβ38) antibodies in Aβ38 level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation.

Monocyte chemoattractant protein-1 (MCP-1/CCL2)

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Alzheimer Disease(AD)
GMP-h-Aβ38-Ag01
beta-amyloid 38 (Aβ38) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Aβ38 level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation
GMP-h-Aβ38-Ab01,GMP-h-Aβ38-Ab02
Human beta-amyloid 38 (Aβ38) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other beta-amyloid 38 (Aβ38) antibodies in Aβ38 level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation.

neurogranin protein (neurogranin)

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Alzheimer Disease(AD)
GMP-h-Aβ38-Ag01
beta-amyloid 38 (Aβ38) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Aβ38 level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation
GMP-h-Aβ38-Ab01,GMP-h-Aβ38-Ab02
Human beta-amyloid 38 (Aβ38) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other beta-amyloid 38 (Aβ38) antibodies in Aβ38 level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation.

neuron-specific enolase (NSE)

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Alzheimer Disease(AD)
GMP-h-Aβ38-Ag01
beta-amyloid 38 (Aβ38) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Aβ38 level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation
GMP-h-Aβ38-Ab01,GMP-h-Aβ38-Ab02
Human beta-amyloid 38 (Aβ38) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other beta-amyloid 38 (Aβ38) antibodies in Aβ38 level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation.

soluble fragment of triggering receptor expressed on myeloid cells 2 (sTREM2)

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Alzheimer Disease(AD)
GMP-h-Aβ38-Ag01
beta-amyloid 38 (Aβ38) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Aβ38 level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation
GMP-h-Aβ38-Ab01,GMP-h-Aβ38-Ab02
Human beta-amyloid 38 (Aβ38) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other beta-amyloid 38 (Aβ38) antibodies in Aβ38 level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation.

Visinin-like protein 1 (VLP-1)

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Alzheimer Disease(AD)
GMP-h-VLP-1-Ag01
Visinin-like protein 1 (VLP-1) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in VLP-1 level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation
GMP-h-VLP-1-Ab01,GMP-h-VLP-1-Ab02
Human Visinin-like protein 1 (VLP-1) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other Visinin-like protein 1 (VLP-1) antibodies in VLP-1 level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation.

Chitinase-3-like protein 1 (CHI3L1/YKL-40)

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Alzheimer Disease(AD)
GMP-h-YKL-40-Ag01
Chitinase-3-like protein 1 (YKL-40) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in YKL-40 level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation
GMP-h-YKL-40-Ab01,GMP-h-YKL-40-Ab02
Human Chitinase-3-like protein 1 (YKL-40) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other Chitinase-3-like protein 1 (YKL-40) antibodies in YKL-40 level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation.

Alpha-synuclein (α-synuclein)

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Alzheimer Disease(AD)
GMP-h-α-synuclein-Ag01
Alpha-synuclein (α-synuclein) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in α-synuclein level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation
GMP-h-α-synuclein-Ab01,GMP-h-α-synuclein-Ab02
Human Alpha-synuclein (α-synuclein) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other Alpha-synuclein (α-synuclein) antibodies in α-synuclein level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation.

AD-associated neuaronal thread protein (AD7c-NTP)

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Alzheimer Disease(AD)
GMP-h-AD7c-NTP-Ag01
AD-associated neuaronal thread protein (AD7c-NTP) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in AD7c-NTP level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation
GMP-h-AD7c-NTP-Ab01,GMP-h-AD7c-NTP-Ab02
Human AD-associated neuaronal thread protein (AD7c-NTP) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other AD-associated neuaronal thread protein (AD7c-NTP) antibodies in AD7c-NTP level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation.
Human

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Alzheimer Disease(AD)
GMP-h-AD7c-NTP-Ag01
AD-associated neuaronal thread protein (AD7c-NTP) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in AD7c-NTP level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation
GMP-h-AD7c-NTP-Ab01,GMP-h-AD7c-NTP-Ab02
Human AD-associated neuaronal thread protein (AD7c-NTP) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other AD-associated neuaronal thread protein (AD7c-NTP) antibodies in AD7c-NTP level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation.