Cytokines and Growth Factors-GeneMedi Descrition: An Lanscape of Cytokines & Growth Factors, including family classification, functional and reagent products list

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Cytokines are small cell-signaling proteins that are secreted by numerous cell types (some of the cytokines are transmembrane proteins). Importantly, most cytokines function in their local microenvironment, rather than in a systemic manner. Cytokines bind to specific cell surface receptors, thereby activating intracellular signaling cascades that involve phosphorylation events that ultimately result in gene transcription. They are crucial to innate and adaptive inflammatory responses, cell growth and differentiation, cell death, angiogenesis and developmental as well as repair processes. Because of their involvement in immune and inflammatory responses, cytokines hold promise as therapeutic targets.

GeneMedi (GM) has plentiful expertise and experience in cytokines & growth factors product development and manufacturing. GM provides various cytokines for applications such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis. The classification of the cytokines includes adipokine, TNF superfamily, VEGF family, chemokines and chemokine receptors, IL-1 family, IL-6 family, IL-10 family, IL-12 family, IL-17 family, activins family, SMAD family, BMP family, IGF family, FGF family, WNT family, GDF family, EGF family, interferons (IFNS) family, NOTCH family, PDGF family, TGF-BETA family, and GDNF family.

Most of GM’s cell-culture grade cytokines and growth factors products are validated and highly evaluated by global researchers both in academia and industry.


Classification

Adipokine TNF Superfamily VEGF Family Chemokines and Chemokine Receptors IL-1 Family IL-6 Family IL-10 Family IL-12 Family IL-17 Family Activins Family SMAD Family BMP Family IGF Family FGF Family Wnt Family GDF Family EGF Family Interferons (IFNs) Family Notch Family PDGF Family TGF-beta Family GDNF Family

Adipokine

Classification: Energy balance and metabolism Brown fat Inflammation Thrombosis and hypertension Growth factors

Energy balance and metabolism

The diversity of the adipokines is considerable, in terms of both protein structure and function. Adipokines in energy metabolism has revealed that adipose tissue is a very important metabolically active endocrine organ. White, brown, and beige adipose tissue generate and secrete adipokines, such as adiponectin, leptin and so on, which facilitate adipose tissue-liver crosstalk and insulin sensitivity. The adipokine secretion pattern reflects adipose tissue function and seems to be important for determining the individual risk to develop metabolic and cardiovascular disease. When adipose tissue inflammation and dysfunction have developed, adipokine secretion is significantly changed towards a diabetogenic, proinflammatory, and atherogenic pattern. Since, adipokines play important roles in the regulation of appetite and satiety, fat distribution, insulin sensitivity and insulin secretion, energy expenditure, inflammation, blood pressure, hemostasis, and endothelial function, they are promising candidate molecules for future treatment of obesity and obesity related diseases. GENEMEDI developed the cytokines related to the energy metabolism such as allergen 1, retinol binding protein 4, plasma, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 dipeptidylpeptidase 4, adiponectin, C1Q and collagen domain containing intelectin 1 (galactofuranose binding), nicotinamide phosphoribosyltransferase, apelin, retinoic acid receptor responder (tazarotene induced) 2, resistin, leptin, complement factor D (adipsin) and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
RBP4Human, Cynomolgus/Rhesus macaque, rat, mouseretinol binding protein 4, plasma (RBP4) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-RBP4 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
SERPINA12Human, Cynomolgus/Rhesus macaque, rat, mouseserpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 (SERPINA12) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-SERPINA12 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
DPP4Human, Cynomolgus/Rhesus macaque, rat, mousedipeptidylpeptidase 4 (DPP4) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-DPP4 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
ITLN1Human, Cynomolgus/Rhesus macaque, rat, mouseintelectin 1 (galactofuranose binding) (ITLN1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-ITLN1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
NAMPTHuman, Cynomolgus/Rhesus macaque, rat, mousenicotinamide phosphoribosyltransferase (NAMPT) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-NAMPT monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
APLNHuman, Cynomolgus/Rhesus macaque, rat, mouseapelin (APLN) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-APLN monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
RARRES2Human, Cynomolgus/Rhesus macaque, rat, mouseretinoic acid receptor responder (tazarotene induced) 2 (RARRES2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-RARRES2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
RETNHuman, Cynomolgus/Rhesus macaque, rat, mouseresistin (RETN) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-RETN monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
LEPHuman, Cynomolgus/Rhesus macaque, rat, mouseleptin (LEP) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-LEP monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CFDHuman, Cynomolgus/Rhesus macaque, rat, mousecomplement factor D (adipsin) (CFD) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CFD monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



Brown fat

Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Brown adipose tissue functions to regulate body temperature through non-shivering thermogenesis; the dissipation of chemical energy to produce heat. Brown and activated beige cells are characterized by high levels of fatty acid β-oxidation, mitochondrial content, and thermogenesis. Activated brown adipocytes alter systemic energy metabolism, increasing substrate oxidation and energy expenditure, with potential for therapeutic exploitation for metabolic diseases including Type 2 diabetes mellitus (T2DM) and obesity. GENEMEDI developed the brown fat such as fibroblast growth factor 21, insulin-like growth factor-I and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
FGF21Human, Cynomolgus/Rhesus macaque, rat, mousefibroblast growth factor 21 (FGF21) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FGF21 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IGF1RHuman, Cynomolgus/Rhesus macaque, rat, mouseInsulin-like Growth Factor-I (IGF1R) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IGF1R monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



Inflammation

The adipokines possess pro- and anti-inflammatory properties and play a critical role in integrating systemic metabolism with immune function. In calorie restriction and starvation, proinflammatory adipokines decline and anti-inflammatory adipokines increase, which informs the host of energy deficits and contributes to the suppression of immune function. In individuals with normal metabolic status, there is a balance of pro- and anti-inflammatory adipokines. This balance shifts to favor proinflammatory mediators as adipose tissue expands during the development of obesity. As a consequence, the proinflammatory status of adipose tissue contributes to a chronic low-grade state of inflammation and metabolic disorders associated with obesity. These disturbances are associated with an increased risk of metabolic disease, type 2 diabetes, cardiovascular disease, and many other pathological conditions. GENEMEDI developed the cytokines related to the adipokines dependent inflammations such as interleukin 10, interleukin 1 alpha, chemokine (C-C motif) ligand 2, interleukin 8, tumor necrosis factor, interleukin 6 and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
IL10Human, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 10 (IL10) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL10 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL1AHuman, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 1, alpha (IL1A) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL1A monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCL2Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) ligand 2 (CCL2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCL2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL8Human, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 8 (IL8) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL8 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFHuman, Cynomolgus/Rhesus macaque, rat, mouseTumor necrosis factor (TNF) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNF monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL6Human, Cynomolgus/Rhesus macaque, rat, mouseInterleukin 6 (IL6) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL6 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



Thrombosis and hypertension

Normal adipose tissue maintains a specifically balanced adipokine profile, which modulates vascular homeostasis via endocrine and paracrine pathways. Excessive accumulation of adipose tissue may alter the expression of the adipokine profile and consequently the physiological effects of adipokines on the vessels. Excessive weight gain contributes to increased blood pressure in most patients with essential hypertension. The involvement of adipose tissue to increase the thrombotic tendency has been proposed through several direct and indirect mechanisms involving endothelial dysfunction together with platelet function abnormalities, enhanced coagulation, and hypo-fribrinolysis. Direct effects include the synthesis and secretion of plasma tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) by adipose tissue, whereas the indirect effects are mainly mediated through the release of adipokines/inflammatory mediators and the oxidative environment which enhance platelet activity, induce liver production of coagulation factors and changes the vessel wall overall contributing to the thrombotic propensity found in obesity. GENEMEDI developed the cytokines related to the thrombosis and hypertension such as angiotensin 1-7, serum amyloid A, C-reactive protein (pentraxin-related), serpin peptidase inhibitor (clade E (nexin, plasminogen activator inhibitor type 1), member 1) and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
CRPHuman, Cynomolgus/Rhesus macaque, rat, mouseC-reactive protein, pentraxin-related (CRP) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CRP monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
SERPINE1Human, Cynomolgus/Rhesus macaque, rat, mouseserpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (SERPINE1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-SERPINE1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



Growth factors

Growth factors are biologically active molecules secreted in the body, which can affect cell growth and promote mitosis. They can cause altered gene expression by affecting various signal transduction pathways. Several growth factors that are either protein (over 50 amino acid residues) or peptides (2–50 amino acid residues) exhibit high affinity for specific receptors on the cell surface. The target receptor cell surface are mainly plasma membrane-bound proteins that show tyrosine kinase activity. Furthermore, some hormones that affect the cell growth such as estrogen and progestogens are considered as growth factors. Recent literature has shown that growth factors are essential for various physiological function such as wound healing and cancer among others. some growth factors that are expressed in adipose tissues have their impact on adipogenesis and other disease conditions. GENEMEDI developed the cytokines related to the growth factor such as hepatocyte growth factor and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
HGFHuman, Cynomolgus/Rhesus macaque, rat, mousehepatocyte growth factor (HGF) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-HGF monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
NGFHuman, Cynomolgus/Rhesus macaque, rat, mouseNerve growth factor (NGF) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-NGF monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



TNF Superfamily

Tumor necrosis factor (TNF) super family composes of a group of cytokines and their receptors which can reduce cell death (apoptosis). TNF is important for immunity and inflammation, and is part of the host response to bacteria, viruses and cancers. Local increases of TNF around sites of injury induce cardinal signs of inflammation, which include heat, swelling, pain and redness. Initially used to treat cancers, in some systems TNF can promote tumor progression. While there are many problems associated with systemic high dose treatment with TNF, recent evidence has demonstrated that local administration in conjunction with interferon γ (IFNγ), promotes the regression of adenomas and melanomas in patients due to apoptosis of the angiogenic endothelium. This superfamily is composed of 19 ligands and 29 receptors in humans. TNFα and Lymphotoxin-alpha (LTα) is first identified members of the family. The TNF family of ligands and receptors has been targeted for use in combination with chemotherapeutic treatment in cancer therapy. GENEMEDI developed the tumor necrosis factor (ligand) superfamily member 13, tumor necrosis factor (ligand) superfamily member 18, tumor necrosis factor receptor superfamily member 22, tumor necrosis factor, alpha-induced protein 8-like 2 and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: TNF Superfamily Ligands TNF Superfamily Regulators

TNF Superfamily Ligands

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
CD154Human, Cynomolgus/Rhesus macaque, rat, mouseCD40 ligand (CD154) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CD154 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CD70Human, Cynomolgus/Rhesus macaque, rat, mouseCD70 antigen (CD70) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CD70 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
EDAHuman, Cynomolgus/Rhesus macaque, rat, mouseectodysplasin A (EDA) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-EDA monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FASLHuman, Cynomolgus/Rhesus macaque, rat, mouseFas ligand (TNF superfamily, member 6) (FASL) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FASL monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
LTBHuman, Cynomolgus/Rhesus macaque, rat, mouselymphotoxin beta (TNF superfamily, member 3) (LTB) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-LTB monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFAIP3Human, Cynomolgus/Rhesus macaque, rat, mousetumor necrosis factor, alpha-induced protein 3 (TNFAIP3) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFAIP3 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFAIP6Human, Cynomolgus/Rhesus macaque, rat, mousetumor necrosis factor, alpha-induced protein 6 (TNFAIP6) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFAIP6 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFRSF10AHuman, Cynomolgus/Rhesus macaque, rat, mouseTumor necrosis factor receptor superfamily, member 10a (TNFRSF10A) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFRSF10A monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFRSF10BHuman, Cynomolgus/Rhesus macaque, rat, mousetumor necrosis factor receptor superfamily, member 10b (TNFRSF10B) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFRSF10B monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFRSF10CHuman, Cynomolgus/Rhesus macaque, rat, mousetumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain (TNFRSF10C) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFRSF10C monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFRSF11AHuman, Cynomolgus/Rhesus macaque, rat, mousetumor necrosis factor receptor superfamily, member 11a, NFKB activator (TNFRSF11A) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFRSF11A monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFRSF11BHuman, Cynomolgus/Rhesus macaque, rat, mousetumor necrosis factor receptor superfamily, member 11b (TNFRSF11B) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFRSF11B monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFRSF12AHuman, Cynomolgus/Rhesus macaque, rat, mouseTumor necrosis factor receptor superfamily, member 12A (TNFRSF12A) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFRSF12A monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFRSF13BHuman, Cynomolgus/Rhesus macaque, rat, mousetumor necrosis factor receptor superfamily, member 13B (TNFRSF13B) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFRSF13B monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFRSF13CHuman, Cynomolgus/Rhesus macaque, rat, mousetumor necrosis factor receptor superfamily, member 13C (TNFRSF13C) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFRSF13C monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFRSF14Human, Cynomolgus/Rhesus macaque, rat, mousetumor necrosis factor receptor superfamily, member 14 (TNFRSF14) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFRSF14 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFRSF17Human, Cynomolgus/Rhesus macaque, rat, mousetumor necrosis factor receptor superfamily, member 17 (TNFRSF17) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFRSF17 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFRSF18Human, Cynomolgus/Rhesus macaque, rat, mousetumor necrosis factor receptor superfamily, member 18 (TNFRSF18) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFRSF18 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFRSF19Human, Cynomolgus/Rhesus macaque, rat, mousetumor necrosis factor receptor superfamily, member 19 (TNFRSF19) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFRSF19 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFRSF1AHuman, Cynomolgus/Rhesus macaque, rat, mouseTumor necrosis factor receptor superfamily, member 1A (TNFRSF1A) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFRSF1A monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFRSF1BHuman, Cynomolgus/Rhesus macaque, rat, mousetumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFRSF1B monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFRSF21Human, Cynomolgus/Rhesus macaque, rat, mouseTumor necrosis factor receptor superfamily, member 21 (TNFRSF21) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFRSF21 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFRSF25Human, Cynomolgus/Rhesus macaque, rat, mousetumor necrosis factor receptor superfamily, member 25 (TNFRSF25) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFRSF25 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFRSF4Human, Cynomolgus/Rhesus macaque, rat, mousetumor necrosis factor receptor superfamily, member 4 (TNFRSF4) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFRSF4 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFRSF6BHuman, Cynomolgus/Rhesus macaque, rat, mousetumor necrosis factor receptor superfamily, member 6b, decoy (TNFRSF6B) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFRSF6B monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFRSF8Human, Cynomolgus/Rhesus macaque, rat, mousetumor necrosis factor receptor superfamily, member 8 (TNFRSF8) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFRSF8 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFRSF9Human, Cynomolgus/Rhesus macaque, rat, mousetumor necrosis factor receptor superfamily, member 9 (TNFRSF9) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFRSF9 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFSF10Human, Cynomolgus/Rhesus macaque, rat, mousetumor necrosis factor (ligand) superfamily, member 10 (TNFSF10) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFSF10 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFSF11Human, Cynomolgus/Rhesus macaque, rat, mousetumor necrosis factor (ligand) superfamily, member 11 (TNFSF11) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFSF11 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFSF12Human, Cynomolgus/Rhesus macaque, rat, mouseTumor necrosis factor superfamily member 12 (TNFSF12) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFSF12 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFSF13Human, Cynomolgus/Rhesus macaque, rat, mousetumor necrosis factor (ligand) superfamily, member 13 (TNFSF13) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFSF13 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFSF13BHuman, Cynomolgus/Rhesus macaque, rat, mousetumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFSF13B monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFSF14Human, Cynomolgus/Rhesus macaque, rat, mouseTumor necrosis factor superfamily member 14 (TNFSF14) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFSF14 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFSF15Human, Cynomolgus/Rhesus macaque, rat, mouseTumor necrosis factor superfamily member 15 (TNFSF15) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFSF15 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFSF18Human, Cynomolgus/Rhesus macaque, rat, mousetumor necrosis factor (ligand) superfamily, member 18 (TNFSF18) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFSF18 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFSF4Human, Cynomolgus/Rhesus macaque, rat, mousetumor necrosis factor (ligand) superfamily, member 4 (TNFSF4) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFSF4 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
Tnfsf8Human, Cynomolgus/Rhesus macaque, rat, mousetumor necrosis factor (ligand) superfamily, member 8 (Tnfsf8) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-Tnfsf8 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TNFSF9Human, Cynomolgus/Rhesus macaque, rat, mousetumor necrosis factor (ligand) superfamily, member 9 (TNFSF9) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TNFSF9 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



TNF Superfamily Regulators

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
TRAF6Human, Cynomolgus/Rhesus macaque, rat, mouseTNF receptor-associated factor 6, E3 ubiquitin protein ligase (TRAF6) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TRAF6 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TRAF7Human, Cynomolgus/Rhesus macaque, rat, mouseTNF receptor-associated factor 7, E3 ubiquitin protein ligase (TRAF7) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TRAF7 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



VEGF Family

Vascular endothelial growth factor (VEGF), originally known as vascular permeability factor (VPF). It is a signal protein produced by many cells that stimulates the formation of blood vessels. To be specific, VEGF is a sub-family of growth factors, the platelet-derived growth factor family of cystine-knot growth factors. They are important signaling proteins involved in both vasculogenesis and angiogenesis. VEGF is part of the system that restores the oxygen supply to tissues when blood circulation is inadequate such as in hypoxic conditions. Serum concentration of VEGF is high in bronchial asthma and diabetes mellitus. It can contribute to disease. Solid cancers cannot grow beyond a limited size without an adequate blood supply; cancers that can express VEGF are able to grow and metastasize. Overexpression of VEGF can cause vascular disease in the retina of the eye and other parts of the body. GENEMEDI developed the c-fos induced growth factor (vascular endothelial growth factor D), fms-related tyrosine kinase 1, fms-related tyrosine kinase 4, Kinase insert domain receptor, placental growth factor, Vascular endothelial growth factor, Vascular endothelial growth factor A, Vascular endothelial growth factor B, Vascular endothelial growth factor C and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: VEGF Family Receptors VEGF Family Ligands

VEGF Family Receptors

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
VEGFBHuman, Cynomolgus/Rhesus macaque, rat, mouseVascular endothelial growth factor B (VEGFB) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-VEGFB monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
VEGFAHuman, Cynomolgus/Rhesus macaque, rat, mouseVascular endothelial growth factor A (VEGFA) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-VEGFA monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FIGFHuman, Cynomolgus/Rhesus macaque, rat, mousec-fos induced growth factor (vascular endothelial growth factor D) (FIGF) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FIGF monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
PGFHuman, Cynomolgus/Rhesus macaque, rat, mouseplacental growth factor (PGF) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-PGF monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



VEGF Family Ligands

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
KDRHuman, Cynomolgus/Rhesus macaque, rat, mouseKinase insert domain receptor (KDR) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-KDR monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FLT1Human, Cynomolgus/Rhesus macaque, rat, mousefms-related tyrosine kinase 1 (FLT1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FLT1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
VEGFCHuman, Cynomolgus/Rhesus macaque, rat, mouseVascular endothelial growth factor C (VEGFC) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-VEGFC monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FLT4Human, Cynomolgus/Rhesus macaque, rat, mousefms-related tyrosine kinase 4 (FLT4) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FLT4 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



Chemokines and Chemokine Receptors

Chemokines are highly conserved cytokines that control the movement of cells around the body. Chemokines, or chemotactic cytokines, are a large family of small soluble proteins, and are distinguished and classified, based on the presence of conserved cysteine residues, as ‘CC’, ‘CXC’, ‘C’ or ‘CX3C’. The receptors, in turn, are classified based on the ligands they bind. Upon binding of the chemokine to a cognate chemokine receptor, the receptor undergoes a conformational change exposing the highly conserved DRYLAIV domain. The exposed motif binds to neighboring G-proteins, kick-starting a signal transduction cascade which will ultimately cause the cell to polarize and initiate migration. The chemokine superfamily includes a large number of ligands that bind to a smaller number of receptors. The importance of the chemokines has grown in recent years, as it has become recognized that they are key players in many disease processes, including inflammation, autoimmune disease, infectious diseases (such as HIV/AIDS), and more recently, cancer (in particular in regulating metastasis). Multiple chemokine ligands can bind to the same receptor; the perceived complexity and promiscuity of receptor binding has often made this field a challenge to understand and given the impression that chemokines lack specific effects. GENEMEDI developed the chemokines receptor and ligand such as atypical chemokine receptor 4, chemokine (C-C motif) receptor 1 to 10, chemokine (C-C motif) receptor-like 2, chemokine (C-X3-C motif) receptor 1, chemokine (C-X-C motif) receptor 1 to 7, family with sequence similarity 19 (chemokine (C-C motif)-like), member A2 to A4, interleukin 8, platelet factor 4, X-C motif chemokine receptor 1, chemokine (C motif) ligand 1 to 28, chemokine (C-X3-C motif) ligand 1, chemokine (C-X-C motif) ligand 1, 2,3, 6, 7, 9 to 16 and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: Chemokines Receptors Chemokines Ligands

Chemokines Receptors

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
CCR1Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) receptor 1 (CCR1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCR1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCR10Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) receptor 10 (CCR10) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCR10 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCR2Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) receptor 2 (CCR2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCR2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCR3Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) receptor 3 (CCR3) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCR3 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCR4Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) receptor 4 (CCR4) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCR4 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCR5Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) receptor 5 (CCR5) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCR5 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCR6Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) receptor 6 (CCR6) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCR6 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCR7Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) receptor 7 (CCR7) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCR7 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCR8Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) receptor 8 (CCR8) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCR8 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCR9Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) receptor 9 (CCR9) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCR9 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCRL1Human, Cynomolgus/Rhesus macaque, rat, mouseatypical chemokine receptor 4 (CCRL1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCRL1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCRL2Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) receptor-like 2 (CCRL2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCRL2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CX3CR1Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-X3-C motif) receptor 1 (CX3CR1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CX3CR1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CXCR1Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-X-C motif) receptor 1 (CXCR1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CXCR1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CXCR2Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-X-C motif) receptor 2 (CXCR2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CXCR2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CXCR3Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-X-C motif) receptor 3 (CXCR3) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CXCR3 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CXCR4Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-X-C motif) receptor 4 (CXCR4) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CXCR4 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CXCR5Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-X-C motif) receptor 5 (CXCR5) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CXCR5 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CXCR6Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-X-C motif) receptor 6 (CXCR6) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CXCR6 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CXCR7Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-X-C motif) receptor 7 (CXCR7) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CXCR7 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
XCR1Human, Cynomolgus/Rhesus macaque, rat, mouseX-C motif chemokine receptor 1 (XCR1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-XCR1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



Chemokines Ligands

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
CCL1Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) ligand 1 (CCL1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCL1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCL11Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) ligand 11 (CCL11) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCL11 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCL13Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) ligand 13 (CCL13) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCL13 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCL14Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) ligand 14 (CCL14) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCL14 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCL15Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) ligand 15 (CCL15) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCL15 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCL16Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) ligand 16 (CCL16) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCL16 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCL17Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) ligand 17 (CCL17) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCL17 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCL18Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) (CCL18) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCL18 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCL19Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) ligand 19 (CCL19) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCL19 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCL20Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) ligand 20 (CCL20) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCL20 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCL21Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) ligand 21 (CCL21) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCL21 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCL22Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) ligand 22 (CCL22) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCL22 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCL23Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) ligand 23 (CCL23) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCL23 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCL24Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) ligand 24 (CCL24) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCL24 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCL25Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) ligand 25 (CCL25) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCL25 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCL26Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) ligand 26 (CCL26) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCL26 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCL27Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) ligand 27 (CCL27) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCL27 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCL28Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) ligand 28 (CCL28) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCL28 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCL3Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) ligand 3 (CCL3) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCL3 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCL5Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) ligand 5 (CCL5) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCL5 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCL7Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) ligand 7 (CCL7) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCL7 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CCL8Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-C motif) ligand 8 (CCL8) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CCL8 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CX3CL1Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-X3-C motif) ligand 1 (CX3CL1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CX3CL1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CXCL1Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-X-C motif) ligand 1 (CXCL1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CXCL1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CXCL10Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-X-C motif) ligand 10 (CXCL10) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CXCL10 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CXCL11Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-X-C motif) ligand 11 (CXCL11) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CXCL11 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CXCL12Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-X-C motif) ligand 12 (CXCL12) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CXCL12 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CXCL13Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-X-C motif) ligand 13 (CXCL13) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CXCL13 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CXCL14Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-X-C motif) ligand 14 (CXCL14) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CXCL14 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CXCL15Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-X-C motif) ligand 15 (CXCL15) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CXCL15 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CXCL16Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-X-C motif) ligand 16 (CXCL16) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CXCL16 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CXCL2Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-X-C motif) ligand 2 (CXCL2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CXCL2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CXCL3Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-X-C motif) ligand 3 (CXCL3) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CXCL3 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CXCL6Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-X-C motif) ligand 6 (CXCL6) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CXCL6 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CXCL9Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C-X-C motif) ligand 9 (CXCL9) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CXCL9 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FAM19A2Human, Cynomolgus/Rhesus macaque, rat, mousefamily with sequence similarity 19 (chemokine (C-C motif)-like), member A2 (FAM19A2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FAM19A2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FAM19A3Human, Cynomolgus/Rhesus macaque, rat, mousefamily with sequence similarity 19 (chemokine (C-C motif)-like), member A3 (FAM19A3) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FAM19A3 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FAM19A4Human, Cynomolgus/Rhesus macaque, rat, mousefamily with sequence similarity 19 (chemokine (C-C motif)-like), member A4 (FAM19A4) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FAM19A4 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
PF4Human, Cynomolgus/Rhesus macaque, rat, mouseplatelet factor 4 (PF4) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-PF4 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
PPBPHuman, Cynomolgus/Rhesus macaque, rat, mousepro-platelet basic protein (chemokine (C-X-C motif) ligand 7) (PPBP) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-PPBP monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
XCL1Human, Cynomolgus/Rhesus macaque, rat, mousechemokine (C motif) ligand 1 (XCL1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-XCL1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



IL-1 Family

IL-1 has served as a ground breaking molecule in immunology and it is now experiencing a renaissance.  The IL-1 family of ligands and receptors is primarily associated with acute and chronic inflammation. The cytosolic segment of each IL-1 receptor family member contains the Toll-IL-1-receptor domain. This domain is also present in each Toll-like receptor, the receptors that respond to microbial products and viruses. Since Toll-IL-1-receptor domains are functional for both receptor families, responses to the IL-1 family are fundamental to innate immunity. The family of IL-1 and IL-1R have been identified and their function has been defined in innate and adaptive immune responses. IL-1 family members have emerged as key players in the differentiation of the main T helper subsets, Th1, Th2, and Th17. Anti-IL-1 strategies have had a tremendous impact in autoinflammatory diseases and are being tested in a variety of clinical conditions. GENEMEDI developed the IL-1 receptor and ligand such as IL-1 F6, IL-1 R6, IL-1 receptor accessory protein, IL-1 receptor accessory protein-like 1, IL-1 receptor antagonist, IL-1 receptor, type I and II, IL-1 receptor-like 1, IL-1 alpha, IL18, IL 18 binding protein, IL 18 receptor 1, IL 2 receptor, type IV, IL 33, IL 36 receptor antagonist, IL 36 beta, IL 36 gamma, IL 37, IL -1 Beta, IL -1 receptor, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, transmembrane emp24 protein transport domain containing 1 and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: IL-1 Receptors IL-1 Ligands IL-18 Binding Proteins

IL-1 Receptors

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
SIGIRRHuman, Cynomolgus/Rhesus macaque, rat, mousesingle immunoglobulin and toll-interleukin 1 receptor (TIR) domain (SIGIRR) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-SIGIRR monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL1R1Human, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 1 receptor, type I (IL1R1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL1R1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL1RL1Human, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 1 receptor-like 1 (IL1RL1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL1RL1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL1R2Human, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 1 receptor, type II (IL1R2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL1R2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL1RL2Human, Cynomolgus/Rhesus macaque, rat, mouseIL-1 R6 (IL1RL2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL1RL2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL1RAPHuman, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 1 receptor accessory protein (IL1RAP) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL1RAP monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TMED1Human, Cynomolgus/Rhesus macaque, rat, mousetransmembrane emp24 protein transport domain containing 1 (TMED1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TMED1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL18R1Human, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 18 receptor 1 (IL18R1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL18R1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL1RAPL1Human, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 1 receptor accessory protein-like 1 (IL1RAPL1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL1RAPL1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



IL-1 Ligands

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
IL18Human, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 18 (IL18) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL18 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
Il1bHuman, Cynomolgus/Rhesus macaque, rat, mouseInterleukin-1 Beta (Il1b) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-Il1b monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL1RNHuman, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 1 receptor antagonist (IL1RN) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL1RN monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL33Human, Cynomolgus/Rhesus macaque, rat, mouseInterleukin 33 (IL33) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL33 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL36AHuman, Cynomolgus/Rhesus macaque, rat, mouseIL-1 F6 (IL36A) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL36A monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL36BHuman, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 36, beta (IL36B) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL36B monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL36GHuman, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 36, gamma (IL36G) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL36G monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL36RNHuman, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 36 receptor antagonist (IL36RN) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL36RN monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL37Human, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 37 (IL37) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL37 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



IL-18 Binding Proteins

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
IL18BPHuman, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 18 binding protein (IL18BP) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL18BP monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



IL-6 Family

Interferons (IFN) are key cytokines with multifaceted antiviral and cell-modulatory properties. Three distinct types of IFN are recognized (I–III) based on structural features, receptor usage, cellular source and biological activities. The type I IFNs include the IFN-alpha family, IFN-beta, -omega, -kappa and Limitin/IFN-zeta and are important for regulating the immune response to viral infection. The type II IFN group includes only IFN-gamma. IFN-gamma is a multifunctional cytokine that exerts anti-proliferative, immunoregulatory, and pro-inflammatory effects important for numerous aspects of the immune response. The type III IFN family includes IL-29/IFN-lambda 1, IL-28A/IFN-lambda 2, IL-28B/IFN-lambda 3, and IFN-lambda 4. Similar to the type I IFNs, type III IFNs have anti-viral, anti-proliferative, and immunoregulatory effects. The action of IFNs is mediated by a complex, partially overlapping, transcriptional program initiated by the interaction with specific receptors. Genetic diversity, with polymorphisms and mutations, can modulate the extent of IFN responses and the susceptibility to infections. Interactions between IFN types may occur, for both antiviral and cell-modulatory effects, in a complex interplay, involving both synergistic and antagonistic effects. Interferon-associated diseases, not related to virus infections may occur, some of them frequently observed in IFN-treated patients. On the whole, IFNs are pleiotropic biologic response modifiers, that, upon activation of thousands of genes, induce a broad spectrum of activities, regulating cell cycle, differentiation, plasma membrane molecules, release of mediators, etc., that can be relevant for cell proliferation, innate and adaptive immunity, hematopoiesis, angiogenesis and other body functions. GENEMEDI developed the interferon, alpha 2, interferon, interferon (alpha, beta and omega) receptor 2, interferon alpha, interferon gamma receptor 1, interferon gamma receptor 2 (interferon gamma transducer 1), interferon zeta, interferon alpha 1, 4, 5, 7, 8, 10,13,14, 16, 17 and 21, interferon beta 1 fibroblast, interferon epsilon, interferon gamma, interferon kappa, interferon lambda 1 and 3, interferon lambda receptor 1, interferon omega 1, interferon-alpha/beta receptor alpha chain-like interferon-gamma and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: IL-6 Family Receptors IL-6 Family Ligands

IL-6 Family Receptors

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
IL11RAHuman, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 11 receptor, alpha (IL11RA) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL11RA monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL31RAHuman, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 31 receptor A (IL31RA) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL31RA monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CRLF1Human, Cynomolgus/Rhesus macaque, rat, mousecytokine receptor-like factor 1 (CRLF1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CRLF1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL6RHuman, Cynomolgus/Rhesus macaque, rat, mouseInterleukin 6 receptor (IL6R) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL6R monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
LIFRHuman, Cynomolgus/Rhesus macaque, rat, mouseleukemia inhibitory factor receptor (LIFR) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-LIFR monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
OSMRHuman, Cynomolgus/Rhesus macaque, rat, mouseoncostatin M receptor (OSMR) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-OSMR monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CNTFRHuman, Cynomolgus/Rhesus macaque, rat, mouseciliary neurotrophic factor receptor (CNTFR) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CNTFR monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL6STHuman, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 6 signal transducer (IL6ST) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL6ST monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



IL-6 Family Ligands

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
Il31Human, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 31 (Il31) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-Il31 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CLCF1Human, Cynomolgus/Rhesus macaque, rat, mousecardiotrophin-like cytokine factor 1 (CLCF1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CLCF1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CTF1Human, Cynomolgus/Rhesus macaque, rat, mousecardiotrophin 1 (CTF1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CTF1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL11Human, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 11 (IL11) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL11 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CNTFHuman, Cynomolgus/Rhesus macaque, rat, mouseciliary neurotrophic factor (CNTF) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CNTF monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
LIFHuman, Cynomolgus/Rhesus macaque, rat, mouseleukemia inhibitory factor (LIF) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-LIF monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
OSMHuman, Cynomolgus/Rhesus macaque, rat, mouseoncostatin M (OSM) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-OSM monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



IL-10 Family

Interleukin-10 (IL-10) is a cytokine that elicits potent anti-inflammatory responses. IL-10 regulates the adaptive arm of the immune response by reducing the antigen presentation potential of innate cells by decreasing their surface major histocompatibility complex (MHC) levels and costimulatory molecules. In addition, IL-10 potently suppresses the production of proinflammatory cytokines from various cell types including monocytes, macrophages and T cells. The IL-10 receptor belongs to the class II cytokine receptor family, other members of which include the receptors for both type I and II interferons, tissue factor and the orphan receptors CRF2–8 and CRF2–9. Several recently discovered members of the cytokine receptor class II family have been shown to be structurally related to the IL-10 receptor. These include the receptors for IL-20 and IL-22. However, while signaling through these receptors seems to activate the same signal transduction components, they lead to different cellular responses, suggesting the presence of additional pathways and regulatory levels. IL-10 exerts its effects by binding to a surface receptor comprised of two IL-10Rα and two IL-10Rβ receptor subunits, which triggers the activation of the JAK1 (Janus kinase 1)/TYK2 (tyrosine kinase 2)/STAT3 (signal transducer and activator of transcription 3)/ STAT1 signalling pathway and the induction of specific gene expression programs. GENEMEDI developed the IL-10 and receptor such as IL-26, IL-10, IL-19, IL-24, IL-20, IL-22, IL-10 receptor beta and alpha, IL-20 receptor subunit alpha and beta, IL-22 receptor alpha 1, IL-22 receptor alpha 2 and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: IL-10 Family Ligands IFNs Receptors IL-10 Family Receptors

IL-10 Family Ligands

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
IL26Human, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 26 (IL26) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL26 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL24Human, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 24 (IL24) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL24 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL20Human, Cynomolgus/Rhesus macaque, rat, mouseInterleukin 20 (IL20) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL20 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL22Human, Cynomolgus/Rhesus macaque, rat, mouseInterleukin 22 (IL22) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL22 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL19Human, Cynomolgus/Rhesus macaque, rat, mouseIL19 (IL19) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL19 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



IFNs Receptors

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
IL10RBHuman, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 10 receptor, beta (IL10RB) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL10RB monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



IL-10 Family Receptors

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
IL10RAHuman, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 10 receptor, alpha (IL10RA) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL10RA monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL20RBHuman, Cynomolgus/Rhesus macaque, rat, mouseInterleukin 20 receptor subunit beta (IL20RB) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL20RB monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL22RA1Human, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 22 receptor, alpha 1 (IL22RA1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL22RA1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL20RAHuman, Cynomolgus/Rhesus macaque, rat, mouseInterleukin 20 receptor subunit alpha (IL20RA) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL20RA monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL22RA2Human, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 22 receptor, alpha 2 (IL22RA2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL22RA2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



IL-12 Family

Interleukin-12 (IL12) is a pro-inflammatory heterodimeric cytokine that stimulates the proliferation of activated T and NK cells, enhances their cytolytic activity, and induces inflammatory process via IFN-γ production. IL12 cytokine produced by myeloid cells, mediate innate and adaptive immunity. It consists of two disulfide-linked subunits, p35 and p40 that act as ligand and binds with the interleukin-12 receptor (IL12R). IL12R is a member of the hematopoietin receptor family that activates the signals via a conserved JAK-STAT intracellular pathway. The receptor consists of two chains IL-12Rβ1 and IL-12Rβ2. IL-12Rβ1 subunit associates with IL-12Rβ2 subunit and forms the receptor complex. The receptor complex binds with IL12 ligand and activates the downstream IL-12 signaling pathway of signal transduction. The interaction of IL12 ligand and IL12R has shown to play a critical role in innate and adaptive immunity and significantly affect immunodeficiency and several infectious diseases. GENEMEDI developed the IL-12 and receptor such as IL12, IL-12 p70, IL-12 receptor, beta 1 and beta 2, IL-12b, IL-23 receptor, IL-23, alpha subunit p19, IL-27, IL-27 receptor, alpha, marmoset interleukin IL-23 and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: IL-12 Family Ligands IL-12 Family Receptors

IL-12 Family Ligands

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
IL12Human, Cynomolgus/Rhesus macaque, rat, mouseInterleukin 12 (IL12) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL12 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL12AHuman, Cynomolgus/Rhesus macaque, rat, mouseIL-12 p70 (IL12A) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL12A monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL12BHuman, Cynomolgus/Rhesus macaque, rat, mouseInterleukin 12b (IL12B) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL12B monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL23Human, Cynomolgus/Rhesus macaque, rat, mouseMarmoset interleukin IL-23 (IL23) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL23 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL23AHuman, Cynomolgus/Rhesus macaque, rat, mouseInterleukin 23, alpha subunit p19 (IL23A) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL23A monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL27Human, Cynomolgus/Rhesus macaque, rat, mouseInterleukin 27 (IL27) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL27 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



IL-12 Family Receptors

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
IL12RB1Human, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 12 receptor, beta 1 (IL12RB1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL12RB1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL12RB2Human, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 12 receptor, beta 2 (IL12RB2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL12RB2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL23RHuman, Cynomolgus/Rhesus macaque, rat, mouseInterleukin 23 receptor (IL23R) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL23R monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL27RAHuman, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 27 receptor, alpha (IL27RA) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL27RA monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



IL-17 Family

IL-17 family of cytokines are known to have pro-inflammatory actions and play a biological role by forming homodimers to bind to specific receptors which allows for signaling. Produced exclusively by Th17 cells and by a variety of innate immune cells, IL-17 members allow for the recruitment of neutrophils and promote a variety of cells to release inflammatory factors, adhesion molecules and growth and cell proliferation factors which contribute to the development of inflammation, immune response, immune rejection and other biologically active processes. IL-17 family consists of six members in mammals, i.e., IL-17A–F. Both IL-17A and IL-17F can stimulate the production of IL-6, IL-8, and granulocyte colony-stimulating factor (G-CSF), making IL-17 family bona fide pro-inflammatory cytokines. The IL-17 receptor family consists of 5 members, IL-17 receptor A (IL-17RA or IL-17R), IL-17 receptor B (IL-17RB or IL-17BR), IL-17 receptor C (IL17RC), IL-17 receptor D (IL-17RD), and IL-17 receptor E (IL17RE). IL-17 family mainly activate nuclear factor-kappaB (NF-κB) pathway through NF-κB activator 1 (Act1) and TNF (tumor necrosis factor) receptor associated factor 6 (TRAF6), and play important roles in promoting autoimmune diseases including rheumatoid arthritis, psoriasis and multiple sclerosis, and in controlling certain bacterial and fungal infections. GENEMEDI developed the interleukin 17, interleukin 17 receptor A, B, C, D and E, interleukin 17B to 17F, interleukin 25, marmoset interleukin IL17 and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: IL-17 Family Receptors IL-17 Family Ligands

IL-17 Family Receptors

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
IL17RAHuman, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 17 receptor A (IL17RA) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL17RA monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL17RBHuman, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 17 receptor B (IL17RB) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL17RB monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL17RCHuman, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 17 receptor C (IL17RC) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL17RC monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL17RDHuman, Cynomolgus/Rhesus macaque, rat, mouseIL17RD interleukin 17 receptor D (IL17RD) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL17RD monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL17REHuman, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 17 receptor E (IL17RE) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL17RE monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



IL-17 Family Ligands

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
IL17Human, Cynomolgus/Rhesus macaque, rat, mouseInterleukin 17 (IL17) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL17 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL17AHuman, Cynomolgus/Rhesus macaque, rat, mouseMarmoset interleukin IL17 (IL17A) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL17A monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL17BHuman, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 17B (IL17B) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL17B monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL17CHuman, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 17C (IL17C) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL17C monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL17DHuman, Cynomolgus/Rhesus macaque, rat, mouseinterleukin 17D (IL17D) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL17D monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL17FHuman, Cynomolgus/Rhesus macaque, rat, mouseInterleukin 17F (IL17F) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL17F monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IL25Human, Cynomolgus/Rhesus macaque, rat, mouseInterleukin 25 (IL25) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IL25 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



Activins Family

Activin has been established as a multifunctional regulatory protein with a broad spectrum of biological effects in developing as well as in mature tissues and organ systems. Activin has been shown to play a major role in proliferation, differentiation, apoptosis, inflammation, immunoregulation, tissue homeostasis and repair. Activin signals are transmitted through two types of transmembrane serine/threonine kinase receptors, type I and type II activin receptors in target cells. Activin receptors are prototypes of single-pass transmembrane serine/threonine kinases. Intriguingly, activin receptors are shared by other TGF-β family proteins, such as myostatin, growth and differentiation factor 11 (GDF11) and nodal. Therefore, several activities of these ligands are redundant with those of activins. GENEMEDI developed the activin modulators, receptor and ligand such as Activin, activin A receptor, type I, IA, IB, IC, IIA, IIB, Follistatin, follistatin-like 1, follistatin-like 3 (secreted glycoprotein), follistatin-like 4, follistatin-like 5, Activin type II receptor, activin A receptor type II-like 1, follistatin-like 4 and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: Activins Receptor Activins Modulators

Activins Receptor

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
ACVR1Human, Cynomolgus/Rhesus macaque, rat, mouseactivin A receptor, type I (ACVR1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-ACVR1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
ACVR1BHuman, Cynomolgus/Rhesus macaque, rat, mouseactivin A receptor, type IB (ACVR1B) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-ACVR1B monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
ACVR1CHuman, Cynomolgus/Rhesus macaque, rat, mouseactivin A receptor, type IC (ACVR1C) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-ACVR1C monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
ACVR2AHuman, Cynomolgus/Rhesus macaque, rat, mouseactivin A receptor, type IIA (ACVR2A) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-ACVR2A monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
ACVR2BHuman, Cynomolgus/Rhesus macaque, rat, mouseactivin A receptor, type IIB (ACVR2B) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-ACVR2B monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
ACVRL1Human, Cynomolgus/Rhesus macaque, rat, mouseactivin A receptor type II-like 1 (ACVRL1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-ACVRL1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



Activins Modulators

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
FSTHuman, Cynomolgus/Rhesus macaque, rat, mousefollistatin (FST) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FST monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FSTL1Human, Cynomolgus/Rhesus macaque, rat, mousefollistatin-like 1 (FSTL1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FSTL1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FSTL3Human, Cynomolgus/Rhesus macaque, rat, mousefollistatin-like 3 (secreted glycoprotein) (FSTL3) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FSTL3 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FSTL4Human, Cynomolgus/Rhesus macaque, rat, mousefollistatin-like 4 (FSTL4) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FSTL4 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FSTL5Human, Cynomolgus/Rhesus macaque, rat, mousefollistatin-like 5 (FSTL5) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FSTL5 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



SMAD Family

Smads are a family of intracellular proteins that mediate signaling by members of the TGF-beta superfamily. Smads are divided into three distinct subgroups based on their different roles in TGF-beta family signal transduction: R-Smads (receptor-regulated), Co-Smads (common partner), and I-Smads (inhibitory). In general, activation of TGF-beta superfamily serine/threonine kinase receptors leads to the phosphorylation of R-Smads (Smads1, 2, 3, 5, and 8). This is followed by recruitment of the Co-Smad (Smad-4) into an R-Smad/Co-Smad complex that translocates to the nucleus to regulate gene expression. I-Smads (Smad6 and Smad7) antagonize this signaling pathway by preventing R-Smads from interacting with the receptor, or by competing with Co-Smads for the generation of R-Smad/Co-Smad complexes. Ligand-induced activation of TGF-β family receptors with intrinsic serine/threonine kinase activity trigger phosphorylation of receptor-regulated Smads (R-Smads). Activated R-Smads form heteromeric complexes with common-partner Smads (Co-Smads), e.g. Smad4, which translocate efficiently to the nucleus, where they regulate, in co-operation with other transcription factors, coactivators and corepressors, the transcription of target genes. Inhibitory Smads act in most cases in an opposite manner from R- and Co-Smads. Like other components in the TGF-β family signaling cascade, Smad activity is intricately regulated. The multifunctional and context dependency of TGF-β family responses are reflected in the function of Smads as signal integrators. Certain Smads are somatically mutated at high frequency in particular types of human cancers. Gene ablation of Smads in the mouse has revealed their critical roles during embryonic development. GENEMEDI developed the linker-phosphorylated Smad3, SMAD family member 2, SMAD family member 4, SMAD family member 9 and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: SMAD Ligands

SMAD Ligands

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
SMAD1Human, Cynomolgus/Rhesus macaque, rat, mouseSMAD family member 1 (SMAD1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-SMAD1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
SMAD2Human, Cynomolgus/Rhesus macaque, rat, mouseSMAD family member 2 (SMAD2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-SMAD2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
SMAD3Human, Cynomolgus/Rhesus macaque, rat, mouseSMAD family member 3 (SMAD3) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-SMAD3 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
SMAD7Human, Cynomolgus/Rhesus macaque, rat, mouseSMAD family member 7 (SMAD7) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-SMAD7 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
SMAD9Human, Cynomolgus/Rhesus macaque, rat, mouseSMAD family member 9 (SMAD9) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-SMAD9 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



Bone morphogenetic proteins family

Bone morphogenetic proteins (BMPs) are secreted cytokines, which exhibit broad spectra of biological activities in various tissues, including bone, cartilage, blood vessels, heart, kidney, neurons, liver and lung. BMPs are members of the transforming growth factor-β (TGF-β) family that bind to type II and type I serine-threonine kinase receptors, and transduce signals through Smad and non-Smad signaling pathways. Recent findings have revealed that BMP signaling is finely tuned by various mechanisms in both positive and negative fashions. Perturbations of BMP signaling pathways are linked to a wide variety of clinical disorders, including vascular diseases, skeletal diseases and cancer. Administration of recombinant BMP ligands and increasing endogenous expression of BMPs provide therapeutic effects on some diseases. The recent development of BMP receptor inhibitors may also prove useful for some clinical diseases induced by hyperactivation of the BMP signaling pathways. GENEMEDI developed the BMP such as amphiregulin, betacellulin, BMP 1, 2, 2a, 2b, 3, 4, 6, 7, 8a, 8b, BMP receptor type IA, type IB, type II (serine/threonine kinase), and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: BMP Ligands BMP Receptor

BMP Ligands

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
BMP1Human, Cynomolgus/Rhesus macaque, rat, mousebone morphogenetic protein 1 (BMP1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-BMP1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
BMP2Human, Cynomolgus/Rhesus macaque, rat, mousebone morphogenetic protein 2 (BMP2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-BMP2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
BMP2AHuman, Cynomolgus/Rhesus macaque, rat, mousebone morphogenetic protein 2a (BMP2A) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-BMP2A monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
bmp2bHuman, Cynomolgus/Rhesus macaque, rat, mousebone morphogenetic protein 2b (bmp2b) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-bmp2b monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
BMP3Human, Cynomolgus/Rhesus macaque, rat, mousebone morphogenetic protein 3 (BMP3) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-BMP3 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
BMP4Human, Cynomolgus/Rhesus macaque, rat, mousebone morphogenetic protein 4 (BMP4) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-BMP4 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
BMP5Human, Cynomolgus/Rhesus macaque, rat, mousebone morphogenetic protein 5 (BMP5) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-BMP5 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
BMP6Human, Cynomolgus/Rhesus macaque, rat, mousebone morphogenetic protein 6 (BMP6) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-BMP6 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
BMP7Human, Cynomolgus/Rhesus macaque, rat, mousebone morphogenetic protein 7 (BMP7) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-BMP7 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
BMP8AHuman, Cynomolgus/Rhesus macaque, rat, mousebone morphogenetic protein 8a (BMP8A) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-BMP8A monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
BMP8BHuman, Cynomolgus/Rhesus macaque, rat, mousebone morphogenetic protein 8b (BMP8B) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-BMP8B monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



BMP Receptor

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
BMPR1AHuman, Cynomolgus/Rhesus macaque, rat, mousebone morphogenetic protein receptor, type IA (BMPR1A) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-BMPR1A monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
BMPR1BHuman, Cynomolgus/Rhesus macaque, rat, mousebone morphogenetic protein receptor, type IB (BMPR1B) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-BMPR1B monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
BMPR2Human, Cynomolgus/Rhesus macaque, rat, mousebone morphogenetic protein receptor, type II (serine/threonine kinase) (BMPR2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-BMPR2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



IGF Family

The insulin-like growth factors (IGF-I and IGF-II) share sequence and structural similarities with insulin. IGFs have four domains in the order B, C, A, and D from the N terminus and three alpha helices making up the core structure. Insulin is produced as a propeptide which, when processed to the mature form, only has the B and A domains on separate chains linked as a dimer by disulphide bonds and having a similar helical structure to the IGFs. In contrast to the critical role of insulin in metabolic control, the IGFs act via the type 1 IGF receptor (IGF-1R) to promote cell proliferation, survival and differentiation. IGFs are essential for normal growth and development, and perturbation of IGF-I expression is associated with acromegaly (increased) or short stature (decreased). Disruption of IGF-II imprinting during development is associated with overgrowth in Beckwith-Wiedemann syndrome, whereas reduced paternal allele expression results in growth retardation in Silver-Russell syndrome. Furthermore, IGFs acting via the IGF-1R play a major role in promoting cancer cell growth and survival. GENEMEDI developed the insulin-like growth factors receptor and ligand such as cartilage intermediate layer protein nucleotide pyrophosphohydrolase, connective tissue growth factor, cysteine-rich, angiogenic inducer, 61, endothelial cell-specific molecule 1, IGF-like family member 1 and 2, IGF-like family receptor 1, insulin-like growth factor 1 and 2, insulin-like growth factor 2 mRNA binding protein 2, insulin-like growth factor 2 receptor, insulin-like growth factor binding protein 1 to 7, insulin-like growth factor binding protein, acid labile subunit, insulin-like growth factor binding protein-like 1, Insulin-like Growth Factor-I, Kazal-type serine peptidase inhibitor domain 1, nephroblastoma overexpressed, WNT1 inducible signaling pathway protein 1 and 3, and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: IGF Binding Proteins / IGFBPs IGF Receptors IGF Ligands IGF Modulators

IGF Binding Proteins / IGFBPs

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
IGFBP1Human, Cynomolgus/Rhesus macaque, rat, mouseinsulin-like growth factor binding protein 1 (IGFBP1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IGFBP1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IGFBP2Human, Cynomolgus/Rhesus macaque, rat, mouseinsulin-like growth factor binding protein 2, 36kDa (IGFBP2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IGFBP2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IGFBP3Human, Cynomolgus/Rhesus macaque, rat, mouseinsulin-like growth factor binding protein 3 (IGFBP3) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IGFBP3 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IGFBP4Human, Cynomolgus/Rhesus macaque, rat, mouseinsulin-like growth factor binding protein 4 (IGFBP4) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IGFBP4 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IGFBP5Human, Cynomolgus/Rhesus macaque, rat, mouseinsulin-like growth factor binding protein 5 (IGFBP5) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IGFBP5 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IGFBP6Human, Cynomolgus/Rhesus macaque, rat, mouseinsulin-like growth factor binding protein 6 (IGFBP6) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IGFBP6 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IGFBP7Human, Cynomolgus/Rhesus macaque, rat, mouseinsulin-like growth factor binding protein 7 (IGFBP7) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IGFBP7 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IGFBPL1Human, Cynomolgus/Rhesus macaque, rat, mouseinsulin-like growth factor binding protein-like 1 (IGFBPL1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IGFBPL1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
KAZALD1Human, Cynomolgus/Rhesus macaque, rat, mouseKazal-type serine peptidase inhibitor domain 1 (KAZALD1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-KAZALD1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



IGF Receptors

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
IGF2RHuman, Cynomolgus/Rhesus macaque, rat, mouseinsulin-like growth factor 2 receptor (IGF2R) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IGF2R monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IGFLR1Human, Cynomolgus/Rhesus macaque, rat, mouseIGF-like family receptor 1 (IGFLR1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IGFLR1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



IGF Ligands

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
IGFL1Human, Cynomolgus/Rhesus macaque, rat, mouseIGF-like family member 1 (IGFL1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IGFL1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IGFL2Human, Cynomolgus/Rhesus macaque, rat, mouseIGF-like family member 2 (IGFL2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IGFL2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IGF1Human, Cynomolgus/Rhesus macaque, rat, mouseinsulin-like growth factor 1 (IGF1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IGF1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IGF2Human, Cynomolgus/Rhesus macaque, rat, mouseinsulin-like growth factor 2 (IGF2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IGF2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



IGF Modulators

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
CILPHuman, Cynomolgus/Rhesus macaque, rat, mousecartilage intermediate layer protein, nucleotide pyrophosphohydrolase (CILP) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CILP monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
WISP3Human, Cynomolgus/Rhesus macaque, rat, mouseWNT1 inducible signaling pathway protein 3 (WISP3) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-WISP3 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
NOVHuman, Cynomolgus/Rhesus macaque, rat, mousenephroblastoma overexpressed (NOV) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-NOV monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CTGFHuman, Cynomolgus/Rhesus macaque, rat, mouseconnective tissue growth factor (CTGF) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CTGF monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
ESM1Human, Cynomolgus/Rhesus macaque, rat, mouseendothelial cell-specific molecule 1 (ESM1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-ESM1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
WISP1Human, Cynomolgus/Rhesus macaque, rat, mouseWNT1 inducible signaling pathway protein 1 (WISP1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-WISP1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IGFALSHuman, Cynomolgus/Rhesus macaque, rat, mouseinsulin-like growth factor binding protein, acid labile subunit (IGFALS) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IGFALS monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CYR61Human, Cynomolgus/Rhesus macaque, rat, mousecysteine-rich, angiogenic inducer, 61 (CYR61) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CYR61 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



Fibroblast growth factors family

Fibroblast growth factors (FGFs) comprise a structurally related family of 22 molecules. FGFs can be grouped into seven subfamilies based on their sequence similarities and functional properties. FGFs bind four high affinity, ligand-dependent FGF receptor tyrosine kinase molecules (FGFR1–4). In the presence of heparan sulfate (HS) glycosaminoglycans, FGFs stably bind FGFRs and lead to the formation of 2:2:2 FGF-FGFR-HS dimers, which enables the cytoplasmic kinase domains to transphosphorylate one another and become activated. FGFR activation results in the stimulation of various signal transduction cascades that have been implicated in multiple aspects of vertebrate and invertebrate embryonic development, tumor growth, angiogenesis, wound healing, and physiology. GENEMEDI developed the FGFs receptor and ligand such as alpha-2-macroglobulin, alpha-2-macroglobulin-like 1, canopy 2 homolog (zebrafish), fibroblast growth factor 1 to 23, fibroblast growth factor binding protein 1 to 3, fibroblast growth factor receptor 1 to 4 and 1a, fibroblast growth factor receptor substrate 2, fibroblast growth factor receptor-like 1, golgi glycoprotein 1, klotho, klotho beta, leucine-rich repeat, immunoglobulin-like and transmembrane domains 3, PTX3, shisa family member 4, sprouty homolog 1 to 3 and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: FGF Ligands FGF Regulators FGF Receptor

FGF Ligands

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
FGF1Human, Cynomolgus/Rhesus macaque, rat, mousefibroblast growth factor 1 (acidic) (FGF1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FGF1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FGF2Human, Cynomolgus/Rhesus macaque, rat, mousefibroblast growth factor 2 (basic) (FGF2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FGF2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FGF3Human, Cynomolgus/Rhesus macaque, rat, mousefibroblast growth factor 3 (FGF3) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FGF3 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FGF4Human, Cynomolgus/Rhesus macaque, rat, mousefibroblast growth factor 4 (FGF4) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FGF4 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FGF5Human, Cynomolgus/Rhesus macaque, rat, mousefibroblast growth factor 5 (FGF5) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FGF5 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FGF6Human, Cynomolgus/Rhesus macaque, rat, mousefibroblast growth factor 6 (FGF6) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FGF6 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FGF7Human, Cynomolgus/Rhesus macaque, rat, mousefibroblast growth factor 7 (FGF7) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FGF7 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FGF8Human, Cynomolgus/Rhesus macaque, rat, mousefibroblast growth factor 8 (FGF8) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FGF8 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FGF9Human, Cynomolgus/Rhesus macaque, rat, mousefibroblast growth factor 9 (glia-activating factor) (FGF9) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FGF9 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FGF10Human, Cynomolgus/Rhesus macaque, rat, mousefibroblast growth factor 10 (FGF10) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FGF10 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FGF14Human, Cynomolgus/Rhesus macaque, rat, mousefibroblast growth factor 14 (FGF14) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FGF14 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FGF16Human, Cynomolgus/Rhesus macaque, rat, mousefibroblast growth factor 16 (FGF16) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FGF16 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FGF17Human, Cynomolgus/Rhesus macaque, rat, mousefibroblast growth factor 17 (FGF17) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FGF17 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FGF18Human, Cynomolgus/Rhesus macaque, rat, mousefibroblast growth factor 18 (FGF18) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FGF18 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FGF19Human, Cynomolgus/Rhesus macaque, rat, mousefibroblast growth factor 19 (FGF19) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FGF19 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FGF20Human, Cynomolgus/Rhesus macaque, rat, mousefibroblast growth factor 20 (FGF20) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FGF20 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FGF22Human, Cynomolgus/Rhesus macaque, rat, mousefibroblast growth factor 22 (FGF22) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FGF22 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FGF23Human, Cynomolgus/Rhesus macaque, rat, mousefibroblast growth factor 23 (FGF23) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FGF23 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



FGF Regulators

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
SPRY3Human, Cynomolgus/Rhesus macaque, rat, mousesprouty homolog 3 (Drosophila) (SPRY3) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-SPRY3 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CNPY2Human, Cynomolgus/Rhesus macaque, rat, mousecanopy 2 homolog (zebrafish) (CNPY2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CNPY2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FGFBP3Human, Cynomolgus/Rhesus macaque, rat, mousefibroblast growth factor binding protein 3 (FGFBP3) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FGFBP3 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
SHISA4Human, Cynomolgus/Rhesus macaque, rat, mouseshisa family member 4 (SHISA4) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-SHISA4 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
SPRY1Human, Cynomolgus/Rhesus macaque, rat, mousesprouty homolog 1, antagonist of FGF signaling (Drosophila) (SPRY1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-SPRY1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
A2ML1Human, Cynomolgus/Rhesus macaque, rat, mousealpha-2-macroglobulin-like 1 (A2ML1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-A2ML1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FRS2Human, Cynomolgus/Rhesus macaque, rat, mousefibroblast growth factor receptor substrate 2 (FRS2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FRS2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
LRIT3Human, Cynomolgus/Rhesus macaque, rat, mouseleucine-rich repeat, immunoglobulin-like and transmembrane domains 3 (LRIT3) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-LRIT3 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
KLHuman, Cynomolgus/Rhesus macaque, rat, mouseklotho (KL) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-KL monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
SPRY2Human, Cynomolgus/Rhesus macaque, rat, mousesprouty homolog 2 (Drosophila) (SPRY2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-SPRY2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
A2MHuman, Cynomolgus/Rhesus macaque, rat, mousealpha-2-macroglobulin (A2M) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-A2M monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FGFBP2Human, Cynomolgus/Rhesus macaque, rat, mousefibroblast growth factor binding protein 2 (FGFBP2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FGFBP2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FGFBP1Human, Cynomolgus/Rhesus macaque, rat, mousefibroblast growth factor binding protein 1 (FGFBP1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FGFBP1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
PTX3Human, Cynomolgus/Rhesus macaque, rat, mousePTX3 (PTX3) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-PTX3 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
KLBHuman, Cynomolgus/Rhesus macaque, rat, mouseklotho beta (KLB) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-KLB monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



FGF Receptor

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
FGFR1Human, Cynomolgus/Rhesus macaque, rat, mouseFibroblast growth factor receptor 1 (FGFR1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FGFR1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FGFR2Human, Cynomolgus/Rhesus macaque, rat, mousefibroblast growth factor receptor 2 (FGFR2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FGFR2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FGFR3Human, Cynomolgus/Rhesus macaque, rat, mousefibroblast growth factor receptor 3 (FGFR3) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FGFR3 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FGFR4Human, Cynomolgus/Rhesus macaque, rat, mouseFibroblast growth factor receptor 4 (FGFR4) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FGFR4 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FGFRL1Human, Cynomolgus/Rhesus macaque, rat, mousefibroblast growth factor receptor-like 1 (FGFRL1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FGFRL1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
GLG1Human, Cynomolgus/Rhesus macaque, rat, mousegolgi glycoprotein 1 (GLG1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-GLG1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



Wnt Family

Wnt signaling is one of the central mechanisms regulating tissue morphogenesis during embryogenesis and repair. The pivot of this signaling cascade is the Wnt ligand, which binds to receptors belonging to the Frizzled family or the ROR1/ROR2 and RYK family. This interaction governs the downstream signaling cascade (canonical/non-canonical), ultimately extending its effect on the cellular cytoskeleton, transcriptional control of proliferation and differentiation, and organelle dynamics. Anomalous Wnt signaling has been associated with several cancers, the most prominent ones being colorectal, breast, lung, oral, cervical, and hematopoietic malignancies. It extends its effect on tumorigenesis by modulating the tumor microenvironment via fine crosstalk between transformed cells and infiltrating immune cells, such as leukocytes. GENEMEDI developed the frizzled class receptor 1 to 10, wingless-related MMTV integration site 3, wingless-type MMTV integration site family member 1, 2, 2B, 3A, 4, 5A, 5B, 6,7A, 7B, 8A, 8B, 9A, 9B, 10A, 10B, 11, 16 and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: Frizzled Receptors Wnt Family Ligands

Frizzled Receptors

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
FZD1Human, Cynomolgus/Rhesus macaque, rat, mousefrizzled class receptor 1 (FZD1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FZD1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FZD2Human, Cynomolgus/Rhesus macaque, rat, mousefrizzled class receptor 2 (FZD2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FZD2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FZD3Human, Cynomolgus/Rhesus macaque, rat, mousefrizzled class receptor 3 (FZD3) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FZD3 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FZD4Human, Cynomolgus/Rhesus macaque, rat, mousefrizzled class receptor 4 (FZD4) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FZD4 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FZD5Human, Cynomolgus/Rhesus macaque, rat, mousefrizzled class receptor 5 (FZD5) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FZD5 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FZD6Human, Cynomolgus/Rhesus macaque, rat, mousefrizzled class receptor 6 (FZD6) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FZD6 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FZD7Human, Cynomolgus/Rhesus macaque, rat, mousefrizzled class receptor 7 (FZD7) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FZD7 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FZD8Human, Cynomolgus/Rhesus macaque, rat, mousefrizzled class receptor 8 (FZD8) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FZD8 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FZD9Human, Cynomolgus/Rhesus macaque, rat, mousefrizzled class receptor 9 (FZD9) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FZD9 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
FZD10Human, Cynomolgus/Rhesus macaque, rat, mousefrizzled class receptor 10 (FZD10) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-FZD10 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



Wnt Family Ligands

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
WNT1Human, Cynomolgus/Rhesus macaque, rat, mousewingless-type MMTV integration site family, member 1 (WNT1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-WNT1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
WNT2Human, Cynomolgus/Rhesus macaque, rat, mousewingless-type MMTV integration site family member 2 (WNT2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-WNT2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
WNT2BHuman, Cynomolgus/Rhesus macaque, rat, mousewingless-type MMTV integration site family, member 2B (WNT2B) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-WNT2B monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
WNT3Human, Cynomolgus/Rhesus macaque, rat, mousewingless-related MMTV integration site 3 (WNT3) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-WNT3 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
WNT3AHuman, Cynomolgus/Rhesus macaque, rat, mousewingless-type MMTV integration site family, member 3A (WNT3A) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-WNT3A monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
WNT4Human, Cynomolgus/Rhesus macaque, rat, mousewingless-type MMTV integration site family, member 4 (WNT4) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-WNT4 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
WNT5AHuman, Cynomolgus/Rhesus macaque, rat, mousewingless-type MMTV integration site family, member 5A (WNT5A) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-WNT5A monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
WNT5BHuman, Cynomolgus/Rhesus macaque, rat, mousewingless-type MMTV integration site family, member 5B (WNT5B) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-WNT5B monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
WNT6Human, Cynomolgus/Rhesus macaque, rat, mousewingless-type MMTV integration site family, member 6 (WNT6) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-WNT6 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
WNT7AHuman, Cynomolgus/Rhesus macaque, rat, mousewingless-type MMTV integration site family, member 7A (WNT7A) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-WNT7A monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
WNT7BHuman, Cynomolgus/Rhesus macaque, rat, mousewingless-type MMTV integration site family, member 7B (WNT7B) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-WNT7B monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
WNT8AHuman, Cynomolgus/Rhesus macaque, rat, mousewingless-type MMTV integration site family, member 8A (WNT8A) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-WNT8A monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
WNT8BHuman, Cynomolgus/Rhesus macaque, rat, mousewingless-type MMTV integration site family, member 8B (WNT8B) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-WNT8B monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
WNT9AHuman, Cynomolgus/Rhesus macaque, rat, mousewingless-type MMTV integration site family, member 9A (WNT9A) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-WNT9A monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
WNT9BHuman, Cynomolgus/Rhesus macaque, rat, mousewingless-type MMTV integration site family, member 9B (WNT9B) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-WNT9B monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
WNT10AHuman, Cynomolgus/Rhesus macaque, rat, mousewingless-type MMTV integration site family, member 10A (WNT10A) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-WNT10A monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
WNT10BHuman, Cynomolgus/Rhesus macaque, rat, mousewingless-type MMTV integration site family, member 10B (WNT10B) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-WNT10B monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
WNT11Human, Cynomolgus/Rhesus macaque, rat, mousewingless-type MMTV integration site family, member 11 (WNT11) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-WNT11 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
WNT16Human, Cynomolgus/Rhesus macaque, rat, mousewingless-type MMTV integration site family, member 16 (WNT16) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-WNT16 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



GDF Family

Growth differentiation factors (GDFs) are a subfamily of proteins belonging to the transforming growth factor beta superfamily that have functions predominantly in development. They are produced as inactive preproproteins which are then cleaved and assembled into active secreted homodimers. GDF dimers are disulfide-linked with the exception of GDF-3 and -9. GDF proteins are important during embryonic development, particularly in the skeletal, nervous, and muscular systems. GENEMEDI developed the Growth differentiation factors such as growth differentiation factor 1 to 3, 5 to 7, 9 to 11, 15 and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: GDF Ligands

GDF Ligands

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
GDF1Human, Cynomolgus/Rhesus macaque, rat, mousegrowth differentiation factor 1 (GDF1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-GDF1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
GDF2Human, Cynomolgus/Rhesus macaque, rat, mousegrowth differentiation factor 2 (GDF2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-GDF2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
GDF3Human, Cynomolgus/Rhesus macaque, rat, mousegrowth differentiation factor 3 (GDF3) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-GDF3 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
GDF5Human, Cynomolgus/Rhesus macaque, rat, mousegrowth differentiation factor 5 (GDF5) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-GDF5 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
GDF6Human, Cynomolgus/Rhesus macaque, rat, mousegrowth differentiation factor 6 (GDF6) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-GDF6 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
GDF7Human, Cynomolgus/Rhesus macaque, rat, mousegrowth differentiation factor 7 (GDF7) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-GDF7 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
GDF9Human, Cynomolgus/Rhesus macaque, rat, mousegrowth differentiation factor 9 (GDF9) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-GDF9 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
GDF10Human, Cynomolgus/Rhesus macaque, rat, mousegrowth differentiation factor 10 (GDF10) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-GDF10 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
GDF11Human, Cynomolgus/Rhesus macaque, rat, mousegrowth differentiation factor 11 (GDF11) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-GDF11 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
GDF15Human, Cynomolgus/Rhesus macaque, rat, mousegrowth differentiation factor 15 (GDF15) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-GDF15 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



Epidermal growth factor family

Epidermal growth factor (EGF), is a growth factor that stimulates cell growth, proliferation, and differentiation by binding to its receptor EGFR. EGF acts by binding with high affinity to epidermal growth factor receptor (EGFR) on the cell surface. This stimulates ligand-induced dimerization,[13] activating the intrinsic protein-tyrosine kinase activity of the receptor (see the second diagram). The tyrosine kinase activity, in turn, initiates a signal transduction cascade that results in a variety of biochemical changes within the cell – a rise in intracellular calcium levels, increased glycolysis and protein synthesis, and increases in the expression of certain genes including the gene for EGFR – that ultimately lead to DNA synthesis and cell proliferation. GENEMEDI developed the Epidermal growth factor receptor and ligand such as EGF-like-domain multiple 6, 7, 8, epidermal growth factor, epidermal growth factor receptor, epiregulin, epithelial mitogen, erbb2 interacting protein, erb-b2 receptor tyrosine kinase 2, 3, 4, heparin-binding EGF-like growth factor, leucine-rich repeats and immunoglobulin-like domains 3, neuregulin 1, 2, 3, 4, phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1, SH3-domain kinase binding protein 1, STAM binding protein, transforming growth factor, alpha, Transmembrane protein with EGF-like and two follistatin-like domains1, and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: EGF Receptor EGF Ligands EGF Regulators

EGF Receptor

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
ERBB4Human, Cynomolgus/Rhesus macaque, rat, mouseerb-b2 receptor tyrosine kinase 4 (ERBB4) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-ERBB4 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
EGFRHuman, Cynomolgus/Rhesus macaque, rat, mouseepidermal growth factor receptor (EGFR) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-EGFR monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



EGF Ligands

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
EGFL8Human, Cynomolgus/Rhesus macaque, rat, mouseEGF-like-domain, multiple 8 (EGFL8) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-EGFL8 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TMEFF2Human, Cynomolgus/Rhesus macaque, rat, mouseTransmembrane protein with EGF-like and two follistatin-like domains 2 (TMEFF2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TMEFF2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
NRG1Human, Cynomolgus/Rhesus macaque, rat, mouseneuregulin 1 (NRG1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-NRG1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TMEFF1Human, Cynomolgus/Rhesus macaque, rat, mousetransmembrane protein with EGF-like and two follistatin-like domains 1 (TMEFF1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TMEFF1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
NRG3Human, Cynomolgus/Rhesus macaque, rat, mouseneuregulin 3 (NRG3) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-NRG3 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
ERBB3Human, Cynomolgus/Rhesus macaque, rat, mouseerb-b2 receptor tyrosine kinase 3 (ERBB3) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-ERBB3 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
EGFL7Human, Cynomolgus/Rhesus macaque, rat, mouseEGF-like-domain, multiple 7 (EGFL7) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-EGFL7 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
BTCHuman, Cynomolgus/Rhesus macaque, rat, mousebetacellulin (BTC) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-BTC monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
EGFHuman, Cynomolgus/Rhesus macaque, rat, mouseepidermal growth factor (EGF) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-EGF monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
NRG2Human, Cynomolgus/Rhesus macaque, rat, mouseneuregulin 2 (NRG2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-NRG2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TGFAHuman, Cynomolgus/Rhesus macaque, rat, mousetransforming growth factor, alpha (TGFA) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TGFA monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
EREGHuman, Cynomolgus/Rhesus macaque, rat, mouseepiregulin (EREG) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-EREG monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
LRIG3Human, Cynomolgus/Rhesus macaque, rat, mouseleucine-rich repeats and immunoglobulin-like domains 3 (LRIG3) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-LRIG3 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
NRG4Human, Cynomolgus/Rhesus macaque, rat, mouseneuregulin 4 (NRG4) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-NRG4 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
LRIG2Human, Cynomolgus/Rhesus macaque, rat, mouseleucine-rich repeats and immunoglobulin-like domains 2 (LRIG2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-LRIG2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
AREGHuman, Cynomolgus/Rhesus macaque, rat, mouseamphiregulin (AREG) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-AREG monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
EGFL6Human, Cynomolgus/Rhesus macaque, rat, mouseEGF-like-domain, multiple 6 (EGFL6) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-EGFL6 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
EPGNHuman, Cynomolgus/Rhesus macaque, rat, mouseepithelial mitogen (EPGN) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-EPGN monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
ERBB2Human, Cynomolgus/Rhesus macaque, rat, mouseerb-b2 receptor tyrosine kinase 2 (ERBB2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-ERBB2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



EGF Regulators

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
STAMBPHuman, Cynomolgus/Rhesus macaque, rat, mouseSTAM binding protein (STAMBP) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-STAMBP monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
ERBB2IPHuman, Cynomolgus/Rhesus macaque, rat, mouseerbb2 interacting protein (ERBB2IP) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-ERBB2IP monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



Interferons (IFNs) Family

Interferons (IFN) are key cytokines with multifaceted antiviral and cell-modulatory properties. Three distinct types of IFN are recognized (I–III) based on structural features, receptor usage, cellular source and biological activities. The type I IFNs include the IFN-alpha family, IFN-beta, -omega, -kappa and Limitin/IFN-zeta and are important for regulating the immune response to viral infection. The type II IFN group includes only IFN-gamma. IFN-gamma is a multifunctional cytokine that exerts anti-proliferative, immunoregulatory, and pro-inflammatory effects important for numerous aspects of the immune response. The type III IFN family includes IL-29/IFN-lambda 1, IL-28A/IFN-lambda 2, IL-28B/IFN-lambda 3, and IFN-lambda 4. Similar to the type I IFNs, type III IFNs have anti-viral, anti-proliferative, and immunoregulatory effects. The action of IFNs is mediated by a complex, partially overlapping, transcriptional program initiated by the interaction with specific receptors. Genetic diversity, with polymorphisms and mutations, can modulate the extent of IFN responses and the susceptibility to infections. Interactions between IFN types may occur, for both antiviral and cell-modulatory effects, in a complex interplay, involving both synergistic and antagonistic effects. Interferon-associated diseases, not related to virus infections may occur, some of them frequently observed in IFN-treated patients. On the whole, IFNs are pleiotropic biologic response modifiers, that, upon activation of thousands of genes, induce a broad spectrum of activities, regulating cell cycle, differentiation, plasma membrane molecules, release of mediators, etc., that can be relevant for cell proliferation, innate and adaptive immunity, hematopoiesis, angiogenesis and other body functions. GENEMEDI developed the interferon, alpha 2, interferon, interferon (alpha, beta and omega) receptor 2, interferon alpha, interferon gamma receptor 1, interferon gamma receptor 2 (interferon gamma transducer 1), interferon zeta, interferon alpha 1, 4, 5, 7, 8, 10,13,14, 16, 17 and 21, interferon beta 1 fibroblast, interferon epsilon, interferon gamma, interferon kappa, interferon lambda 1 and 3, interferon lambda receptor 1, interferon omega 1, interferon-alpha/beta receptor alpha chain-like interferon-gamma and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: IFNs Receptors IFNs Type I IFNs Type II IFNs Type III

IFNs Receptors

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
IFNGR1Human, Cynomolgus/Rhesus macaque, rat, mouseinterferon gamma receptor 1 (IFNGR1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IFNGR1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IFNGR2Human, Cynomolgus/Rhesus macaque, rat, mouseinterferon gamma receptor 2 (interferon gamma transducer 1) (IFNGR2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IFNGR2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IFNAR1Human, Cynomolgus/Rhesus macaque, rat, mouseinterferon-alpha/beta receptor alpha chain-like (IFNAR1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IFNAR1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IFNAR2Human, Cynomolgus/Rhesus macaque, rat, mouseinterferon (alpha, beta and omega) receptor 2 (IFNAR2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IFNAR2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IFNLR1Human, Cynomolgus/Rhesus macaque, rat, mouseinterferon, lambda receptor 1 (IFNLR1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IFNLR1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



IFNs Type I

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
IFNA1Human, Cynomolgus/Rhesus macaque, rat, mouseinterferon, alpha 1 (IFNA1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IFNA1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IFNA2Human, Cynomolgus/Rhesus macaque, rat, mouseIFNA2 interferon, alpha 2 (IFNA2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IFNA2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IFNA4Human, Cynomolgus/Rhesus macaque, rat, mouseinterferon, alpha 4 (IFNA4) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IFNA4 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IFNA5Human, Cynomolgus/Rhesus macaque, rat, mouseinterferon, alpha 5 (IFNA5) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IFNA5 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IFNA7Human, Cynomolgus/Rhesus macaque, rat, mouseinterferon, alpha 7 (IFNA7) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IFNA7 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IFNA8Human, Cynomolgus/Rhesus macaque, rat, mouseinterferon, alpha 8 (IFNA8) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IFNA8 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IFNA10Human, Cynomolgus/Rhesus macaque, rat, mouseinterferon, alpha 10 (IFNA10) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IFNA10 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IFNA13Human, Cynomolgus/Rhesus macaque, rat, mouseinterferon, alpha 13 (IFNA13) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IFNA13 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IFNA14Human, Cynomolgus/Rhesus macaque, rat, mouseinterferon, alpha 14 (IFNA14) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IFNA14 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IFNA16Human, Cynomolgus/Rhesus macaque, rat, mouseinterferon, alpha 16 (IFNA16) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IFNA16 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IFNA17Human, Cynomolgus/Rhesus macaque, rat, mouseinterferon, alpha 17 (IFNA17) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IFNA17 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IFNA21Human, Cynomolgus/Rhesus macaque, rat, mouseinterferon, alpha 21 (IFNA21) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IFNA21 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IFNB1Human, Cynomolgus/Rhesus macaque, rat, mouseinterferon, beta 1, fibroblast (IFNB1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IFNB1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IFNEHuman, Cynomolgus/Rhesus macaque, rat, mouseinterferon, epsilon (IFNE) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IFNE monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IFNKHuman, Cynomolgus/Rhesus macaque, rat, mouseinterferon, kappa (IFNK) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IFNK monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IFNW1Human, Cynomolgus/Rhesus macaque, rat, mouseinterferon, omega 1 (IFNW1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IFNW1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



IFNs Type II

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
IFNGHuman, Cynomolgus/Rhesus macaque, rat, mouseinterferon, gamma (IFNG) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IFNG monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



IFNs Type III

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
IFNL3Human, Cynomolgus/Rhesus macaque, rat, mouseinterferon, lambda 3 (IFNL3) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IFNL3 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
IFNL1Human, Cynomolgus/Rhesus macaque, rat, mouseinterferon, lambda 1 (IFNL1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-IFNL1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



Notch Family

Notch proteins are a family of type-1 transmembrane proteins that form a core component of the Notch signaling pathway. The Notch extracellular domain mediates interactions with DSL family ligands, allowing it to participate in juxtacrine signaling. The Notch intracellular domain acts as a transcriptional activator when in complex with CSL family transcription factors. Members of this Type 1 transmembrane protein family share several core structures, including an extracellular domain consisting of multiple epidermal growth factor (EGF)-like repeats and an intracellular domain transcriptional activation domain (TAD). Notch family members operate in a variety of different tissues and play a role in a variety of developmental processes by controlling cell fate decisions and operating in a great number of biological processes in several organ systems, such as hematopoiesis, somatogenesis, vasculogenesis, neurogenesis and homeostasis. The Notch signaling pathway is crucial for the majority of developmental programs and regulates multiple pathogenic processes. Notch family receptors’ activation has been largely related to its multiple effects in sustaining oncogenesis. The Notch signaling pathway constitutes an ancient and conserved mechanism for cell-to-cell communication. Notch signaling is heavily influenced by microenvironmental cues, including adjacent “sending cells” which present any of five Notch ligands to up to four Notch receptors expressed on so called “receiving cells”. Ligand bound and activated Notch receptors undergo a series of proteolytic cleavages which release an active intracellular domain (NICD). This transcriptionally active fragment translocates to the nucleus to act as a co-transcription factor. Common Notch signaling targets are transcription factors themselves, which have their own broader implications and cascades, culminating in a system that requires a fine-tuned, highly sensitive signaling network. Disruption of Notch signaling, both through over- and under-activation, leads to a variety of developmental abnormalities and cancers. Understanding mechanisms behind this precise level of internal control may pave the way for treatments of many of its resulting disorders. GENEMEDI developed the notch homolog 1, notch 2, notch 3, notch 4 and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: Notch Receptors

Notch Receptors

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
NOTCH1Human, Cynomolgus/Rhesus macaque, rat, mouseNotch homolog 1 (NOTCH1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-NOTCH1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
NOTCH2Human, Cynomolgus/Rhesus macaque, rat, mousenotch 2 (NOTCH2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-NOTCH2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
NOTCH3Human, Cynomolgus/Rhesus macaque, rat, mousenotch 3 (NOTCH3) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-NOTCH3 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
NOTCH4Human, Cynomolgus/Rhesus macaque, rat, mousenotch 4 (NOTCH4) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-NOTCH4 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



Platelet-derived growth factor family

Platelet-derived growth factor (PDGF) is one among numerous growth factors that regulate cell growth and division. In particular, PDGF plays a significant role in blood vessel formation, the growth of blood vessels from already-existing blood vessel tissue, mitogenesis, i.e. proliferation, of mesenchymal cells such as fibroblasts, osteoblasts, tenocytes, vascular smooth muscle cells and mesenchymal stem cells as well as chemotaxis, the directed migration, of mesenchymal cells. However, overactivity of PDGF signaling has been associated with the development of malignancies and other diseases involving excess cell proliferation. The PDGF family consists of PDGF-A, PDGF-B, PDGF-C and PDGF -D. The four PDGFs are inactive in their monomeric forms. The PDGFs bind to the protein tyrosine kinase receptors PDGF receptor-α and -β. These two receptor isoforms dimerize upon binding the PDGF dimer, leading to three possible receptor combinations, namely -αα, -ββ and -αβ. The PDGF signalling network consists of five ligands, PDGF-AA through -DD (including -AB), and two receptors, PDGFR alpha and PDGFR beta. All PDGFs function as secreted, disulphide-linked homodimers, but only PDGFA and B can form functional heterodimers. GENEMEDI developed the Platelet-derived growth factor (PDGF), platelet derived growth factor C, platelet derived growth factor D, platelet derived growth factor subunit B, platelet-derived growth factor alpha polypeptide, Platelet-derived growth factor receptor B, platelet-derived growth factor receptor-like, Platelet-derived growth factor receptors (PDGF-R) and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: PDGF Family Receptors PDGF Family Ligands

PDGF Family Receptors

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
PDGFRAHuman, Cynomolgus/Rhesus macaque, rat, mousePlatelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of theplatelet-derived growth factor (PDGF) family. PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiat (PDGFRA) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-PDGFRA monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
PDGFRLHuman, Cynomolgus/Rhesus macaque, rat, mouseplatelet-derived growth factor receptor-like (PDGFRL) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-PDGFRL monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
PDGFRBHuman, Cynomolgus/Rhesus macaque, rat, mousePlatelet-derived growth factor receptor B (PDGFRB) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-PDGFRB monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



PDGF Family Ligands

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
PDGFAHuman, Cynomolgus/Rhesus macaque, rat, mouseplatelet-derived growth factor alpha polypeptide (PDGFA) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-PDGFA monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
PDGFBHuman, Cynomolgus/Rhesus macaque, rat, mouseplatelet derived growth factor subunit B (PDGFB) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-PDGFB monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
PDGFCHuman, Cynomolgus/Rhesus macaque, rat, mouseplatelet derived growth factor C (PDGFC) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-PDGFC monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
PDGFDHuman, Cynomolgus/Rhesus macaque, rat, mouseplatelet derived growth factor D (PDGFD) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-PDGFD monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



TGF-beta Family

The transforming growth factor beta (TGF-β) superfamily is a large family of growth factors named after the first member TGF-β1. TGF-β superfamily is involved in regulating and mediating processes at the cellular level, including cell proliferation, differentiation, motility, adhesion and apoptosis, as well as processes at the tissue and organism level, including development, wound healing, fibrosis and angiogenesis. The TGF-β superfamily consists of ligands and receptors that all signal, at least in part, through well characterized downstream mediators termed the Smads. The Transforming Growth Factor Beta (TGF-beta) superfamily consists of the TGF-beta proteins, Bone Morphogenetic Proteins (BMPs), Growth Differentiation Factors (GDFs), Glial-derived Neurotrophic Factors (GDNFs), Activins, Inhibins, Nodal, Lefty, and Mülllerian Inhibiting Substance (MIS). Ligands of the TGF-beta superfamily form dimers that bind to heterodimeric receptor complexes consisting of type I and type II receptor subunits with serine/threonine kinase domains. Following ligand binding, the type II receptor phosphorylates and activates the type I receptor, initiating a Smad-dependent signaling cascade that induces or represses transcriptional activity. Disruption of the TGF-β pathway has been implicated in many human diseases, including solid and hematopoietic tumors. As a potent inhibitor of cell proliferation, TGF-β acts as a tumor suppressor; however, in tumor cells, TGF-β loses anti-proliferative response and become an oncogenic factor. GENEMEDI developed the CD109 molecule, transforming growth factor beta 1 induced transcript 1, transforming growth factor beta receptor III, transforming growth factor beta-induced 68kDa and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: TGF-β Receptors TGF-β Ligands

TGF-β Receptors

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
TGFBR1Human, Cynomolgus/Rhesus macaque, rat, mousetransforming growth factor, beta receptor 1 (TGFBR1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TGFBR1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TGFBR2Human, Cynomolgus/Rhesus macaque, rat, mousetransforming growth factor, beta receptor II (70/80kDa) (TGFBR2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TGFBR2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TGFBR3Human, Cynomolgus/Rhesus macaque, rat, mousetransforming growth factor, beta receptor III (TGFBR3) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TGFBR3 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
CD109Human, Cynomolgus/Rhesus macaque, rat, mouseCD109 molecule (CD109) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-CD109 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



TGF-β Ligands

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
TGFBIHuman, Cynomolgus/Rhesus macaque, rat, mousetransforming growth factor, beta-induced, 68kDa (TGFBI) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TGFBI monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TGFB3Human, Cynomolgus/Rhesus macaque, rat, mousetransforming growth factor, beta 3 (TGFB3) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TGFB3 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TGFB2Human, Cynomolgus/Rhesus macaque, rat, mousetransforming growth factor, beta 2 (TGFB2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TGFB2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
TGFB1Human, Cynomolgus/Rhesus macaque, rat, mousetransforming growth factor, beta 1 (TGFB1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-TGFB1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



Glial cell line-derived neurotrophic factor family

Glial cell line-derived neurotrophic factor (GDNF) family members are known to play a role in the developing and adult parasympathetic and enteric nervous systems. GDNF is a disulfide-linked, homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin.  These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures.  GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRα (α1-α4) receptors.  GDNF specifically promotes dopamine uptake and survival, and morphological differentiation of midbrain neurons. GENEMEDI developed the GDNF such as Artemin, GDNF family receptor alpha 1 to 4, GDNF family receptor alpha like, glial cell derived neurotrophic factor, neurturin, persephin and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: GDNF Receptor GDNF Ligands

GDNF Receptor

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
GFRALHuman, Cynomolgus/Rhesus macaque, rat, mouseGDNF family receptor alpha like (GFRAL) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-GFRAL monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
GFRA1Human, Cynomolgus/Rhesus macaque, rat, mouseGDNF family receptor alpha 1 (GFRA1) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-GFRA1 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
GFRA2Human, Cynomolgus/Rhesus macaque, rat, mouseGDNF family receptor alpha 2 (GFRA2) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-GFRA2 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
GFRA3Human, Cynomolgus/Rhesus macaque, rat, mouseGDNF family receptor alpha 3 (GFRA3) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-GFRA3 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
GFRA4Human, Cynomolgus/Rhesus macaque, rat, mouseGDNF family receptor alpha 4 (GFRA4) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-GFRA4 monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.



GDNF Ligands

Target Species Antigen Product Name Bioactivity validation of Antigen Antibody Product Name Bioactivity validation of Antibodies Order
ARTNHuman, Cynomolgus/Rhesus macaque, rat, mouseartemin (ARTN) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-ARTN monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
GDNFHuman, Cynomolgus/Rhesus macaque, rat, mouseglial cell derived neurotrophic factor (GDNF) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-GDNF monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
PSPNHuman, Cynomolgus/Rhesus macaque, rat, mousepersephin (PSPN) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-PSPN monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.
NRTNHuman, Cynomolgus/Rhesus macaque, rat, mouseneurturin (NRTN) proteinAffintiy&bioactivity validated by ELISA, cell culture validatedAnti-NRTN monoclonal antibodyBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).Picture loading failed.