Introduction Mycoplasma are small, simple bacteria which lack a cell wall and resistant to many common antibiotics such as penicillin and streptomycin. Once infect, they can induce changes to the cell cultures, including altered growth rates, morphological changes, chromosomal aberrations, and altered cell metabolism. Thus, contamination of mycoplasma is a major problem in cell culture […]
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Information Introduction to Gene Synthesis and CDNA(ORF) cloning Gene synthesis is a synthetic biological technique, which is the most widely used in biological research. The synthesis of DNA encoding regulatory elements, genes, pathways and entire genomes provides us powerful ways for both test biological hypotheses and harness biology. The emerging field of synthetic biology is […]
NIH Guidelines for AAV Lentivirus and Adenovirus Guidance for Gene Therapy Clinical trials-FDA Human Gene Therapy For Rare Diseases Human Gene Therapy for Retinal Disorders
Protocols Protocol of SARS-CoV-2 Pseudovirus (PSV)-Based Neutralization Assay For Vaccines, therapeutic antibodies, peptides and compounds against COVID-19 GeneMedi’s Pseudovirus Based Neutralization Assay (PBNA) is a conventional assay method that is suitable for High-Throughout Screening (HTS) without live virus engaged. Read More Preparation of AuNP conjugates with recombinant antigens, protein or antibodies for immunoassay — Diagnostic […]
CRISPR/Cas9 premade products CRISPR Editas Medicines Genome editing firm that researches and develops therapies for treating genetic based diseases primarily using CRISPR technology. CEO: Cynthia Collins Website: https://www.editasmedicine.com/ Located: Cambridge, Massachusetts Employees: 133 Market Cap: $22.06 (use link for updated value) Annual Revenue (2018): $30.1M Funding History: Series A funding of $43M via Flagship Ventures achieved in November 2013, Series B funding of $120M […]
Protocol Download Introduction to LipoGene Transfectin Reagent GeneMedi provide LipoGeneTM transfection reagent which is highly potent cationic lipofection reagent that has been shown to effectively transfect plasmids or siRNA, as well as nucleic acid-protein complexes, into cultured adherent and suspension cell lines. Researchers use LipoGeneTM Reagent for siRNA- and shRNA-based gene knockdown experiments, as well as […]
Guidelines EMA COVID-19 vaccines against SARS-CoV-2(2019nCoV) studies for approval guidance The European Medicines Agency (EMA) needs many detailed studies to confirm that a vaccine is safe, provides adequate protection and is of suitable quality. As a public-health body safeguarding medicines in the European Union (EU), EMA will only approve a vaccine for COVID-19 after a […]
Gene transduction and gene transfection Knowledge base CRISPR/Cas9 system and Gene editing therapy Gene therapy, to be brief, is delivering corrective gene materials into cells to treat or alleviate the symptom of disease, so far, including gene editing therapy mediated by CRISPR/Cas sytem, ZFN or TALEN etc., and gene replacement, such as lentivirus/adenovirus/AAV-mediated gene expression. Read More […]
Lentivirus Protocol Download Cell therapy is a kind of medicine aiming to cure disease or alleviate disease symptoms via direct infusion or transplantation of cells, which can be autologous or allogeneic. With several decades’ development and optimization, immuno-oncology cells (such as T cells, nature killer cells, etc.), stem cells (embryonic stem cells, induced pluripotent stem […]
The Landscape of Neutralizing antibodies (NAb): Production, Mechanisms of Action (MOA), FDA approved-antibodies, and Functional assay FDA approved neutralizing antibodies (NAb) and our products 1. SARS-CoV-2 neutralizing antibodies (NAb) SARS-CoV-2, the novel coronavirus responsible for the ongoing COVID-19 pandemic, has been spreading rampantly. The global scientific community has responded rapidly to understand immune correlates of […]
