Hepatitis B virus (HBV) neutralizing antibodies (NAb) Hepatitis B virus (HBV) surface antigen (HBsAg) is considered to be the most important target for the diagnosis and immune prophylaxis of HBV infection. HBsAg-specific monoclonal antibodies (MAbs) are extensively used for studying the complex structure of the HBsAg, mapping the neutralizing epitopes and development of HBV diagnostic […]
Category Archives: nab
Human Immunodeficiency Virus (HIV) neutralizing antibodies (NAb) The glycoprotein (gp) 120 subunit is an important part of the envelope spikes that decorate the surface of HIV-1 and a major target for neutralizing antibodies. FDA approved neutralizing antibodies (NAb) and our products 1. SARS-CoV-2 neutralizing antibodies (NAb) SARS-CoV-2, the novel coronavirus responsible for the ongoing COVID-19 […]
SARS-CoV-2 neutralizing antibodies (NAb) SARS-CoV-2, the novel coronavirus responsible for the ongoing COVID-19 pandemic, has been spreading rampantly. The global scientific community has responded rapidly to understand immune correlates of protection to develop vaccines and immunotherapeutic against the virus. The RBD of spike plays a critical role in the very first step of the virus […]
FDA approved neutralizing antibodies (NAb) and our products 1. SARS-CoV-2 neutralizing antibodies (NAb) SARS-CoV-2, the novel coronavirus responsible for the ongoing COVID-19 pandemic, has been spreading rampantly. The global scientific community has responded rapidly to understand immune correlates of protection to develop vaccines and immunotherapeutic against the virus. The RBD of spike plays a critical […]
Definition–What is neutralizing antibody (NAb)? Regarding neutralizing antibody activity, Neutralization can be achieved through four main mechanisms2: (1)NAbs binding to viral surface proteins and blocking their interaction with the host cell receptor and infection; (2)NAbs binding to viral protein epitopes that interact with host cell coreceptors that are key for viral infection; (3)NAbs binding to viral […]
How to produce neutralizing antibody (NAb) (production) Antibodies are made by B-cells in the bone marrow. Bone marrow has been long thought to be a hematopoietic organ. When B-cells are created, they begin to produce antibodies that will bind to specific antigens. Antigen-specific antibody producing, long-term lived plasma cells are largely found in the bone […]
Definition–What is neutralizing antibody (NAb)? A neutralizing antibody (NAb) is an antibody that is responsible for defending cells from pathogens, which are organisms that cause disease. They are produced naturally by the body as part of its immune response, and their production is triggered by both infections and vaccinations against infections1. A neutralising antibody rapid […]
Measles virus (MeV) neutralizing antibodies (NAb) Measles virus (MeV) causes an extremely transmissible respiratory disease and it has also been used as an oncolytic platform. MeV enter into the cells through the cellular receptors such as SLAM (signaling lymphocyte-activating molecule) and PVRL4 (poliovirus receptor-like 4) (nectin-4). Hence, the antibodies against PVRL4 could block measles virus infections. […]
Pseudomonas aeruginosa infections neutralizing antibodies (NAb) Pseudomonas aeruginosa is a main source of health-care related infections, including pneumonia and infections associated with urinary tract, wounds, burns, and the bloodstream. P. aeruginosa invades the eukaryotic host cells through the type III secretion system (T3SS). This T3SS helps the bacteria to translocate effector proteins directly into host cells. Mammalian immune […]
Human endogenous retroviral envelope protein HERV-W-Env neutralizing antibodies (NAb) Temelimab (formerly called GNbAC1) is an immunoglobulin (Ig) G4 monoclonal antibody that targets the human endogenous retroviral envelope protein HERV-W-Env, shown to be associated with the pathogenesis of certain autoimmune disorders such as multiple sclerosis (MS) and type 1 diabetes mellitus (T1D). By neutralizing HERV-W-Env, temelimab […]
