FDA approved neutralizing antibodies (NAb) and our products

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FDA approved neutralizing antibodies (NAb) and our products

1. SARS-CoV-2 neutralizing antibodies (NAb)

SARS-CoV-2, the novel coronavirus responsible for the ongoing COVID-19 pandemic, has been spreading rampantly. The global scientific community has responded rapidly to understand immune correlates of protection to develop vaccines and immunotherapeutic against the virus. The RBD of spike plays a critical role in the very first step of the virus life cycle. The neutralizing antibodies (nAbs) that target the receptor binding domain (RBD) of viral spike (S) glycoprotein3.

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Pre-Made Bamlanivimab biosimilar, Whole Mab: Anti-SARS-CoV-2 Spike therapeutic antibody
Bamlanivimab
NA
SARS-CoV-2 Spike
Whole mAb
Pre-Made Casirivimab biosimilar, Whole Mab: Anti-SARS-CoV-2 Spike RBD therapeutic antibody
Casirivimab
NA
SARS-CoV-2Spike RBD
Whole mAb
Pre-Made Cilgavimab biosimilar, Whole Mab: Anti-SARS-CoV-2 Spike RBD therapeutic antibody
Cilgavimab
NA
SARS-CoV-2 Spike RBD
Whole mAb
Pre-Made Etesevimab biosimilar, Whole Mab: Anti-SARS-CoV-2 Spike RBD therapeutic antibody
Etesevimab
NA
SARS-CoV-2 Spike RBD
Whole mAb
Pre-Made Imdevimab biosimilar, Whole Mab: Anti-SARS-CoV-2 Spike RBD therapeutic antibody
Imdevimab
NA
SARS-CoV-2 Spike RBD
Whole mAb
Pre-Made Sotrovimab biosimilar, Whole Mab: Anti-SARS-CoV-2 Spike RBD therapeutic antibody
Sotrovimab
NA
SARS-CoV-2 Spike RBD
Whole mAb
Pre-Made Tixagevimab biosimilar, Whole Mab: Anti-SARS-CoV-2 Spike RBD therapeutic antibody
Tixagevimab
NA
SARS-CoV-2 Spike RBD
Whole mAb
Pre-Made Adintrevimab biosimilar, Whole Mab: Anti-SARS-CoV-2 Spike therapeutic antibody
Adintrevimab
NA
SARS-CoV-2 Spike
Whole mAb
Pre-Made Amubarvimab biosimilar, Whole Mab: Anti-SARS-CoV-2 Spike RBD therapeutic antibody
Amubarvimab
NA
SARS-CoV-2 Spike RBD
Whole mAb
Pre-Made Beludavimab biosimilar, Whole Mab: Anti-SARS-CoV-2 Spike RBD therapeutic antibody
Beludavimab
NA
SARS-CoV-2 Spike RBD
Whole mAb
Pre-Made Enuzovimab biosimilar, Whole Mab: Anti-SARS-CoV-2 Spike RBD therapeutic antibody
Enuzovimab
NA
SARS-CoV-2 Spike RBD
Whole mAb
Pre-Made Lomtegovimab biosimilar, Whole Mab: Anti-SARS-CoV-2 Spike RBD therapeutic antibody
Lomtegovimab
NA
SARS-CoV-2 Spike RBD
Whole mAb
Pre-Made Rimteravimab biosimilar, Whole Mab: Anti-SARS-CoV-2 Spike RBD therapeutic antibody
Rimteravimab
NA
SARS-CoV-2 Spike RBD
Mixed Nanobody (VHH-CH2-CH3 dimer)
Pre-Made Romlusevimab biosimilar, Whole Mab: Anti-SARS-CoV-2 Spike RBD therapeutic antibody
Romlusevimab
NA
SARS-CoV-2 Spike RBD
Whole mAb
Pre-Made Upanovimab biosimilar, Whole Mab: Anti-SARS-CoV-2 Spike RBD therapeutic antibody
Upanovimab
NA
SARS-CoV-2 Spike RBD
Whole mAb
Pre-Made Ensovibep biosimilar, Recombinant Protein: Recombinant therapeutic protein targeting Severe?acute?respiratory syndrome?coronavirus?2 RBD
ensovibep
NA
Severe?acute?respiratory syndrome?coronavirus?2 RBD
Recombinant Protein

2. Human Immunodeficiency Virus (HIV) neutralizing antibodies (NAb)

The glycoprotein (gp) 120 subunit is an important part of the envelope spikes that decorate the surface of HIV-1 and a major target for neutralizing antibodies.

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Pre-Made Elipovimab biosimilar, Whole Mab: Anti-HIV-1 gp120 therapeutic antibody
Elipovimab
HIV-1 gp120
Whole mAb
Pre-Made Suvizumab biosimilar, Whole Mab: Anti-HIV-1 gp120 therapeutic antibody
Suvizumab
HIV-1 gp120
Whole mAb
Pre-Made Teropavimab biosimilar, Whole Mab: Anti-HIV-1 gp120 CD4bs therapeutic antibody
Teropavimab
HIV-1 gp120 CD4bs
Whole mAb
Pre-Made Alvircept Sudotox biosimilar, Fusion Protein: Recombinant therapeutic protein targeting HIV-1 gp120 fused with Pseudomonas aeruginosa exotoxin A
alvircept sudotox
HIV-1 gp120
Fusion Protein

3. Hepatitis B virus (HBV) neutralizing antibodies (NAb)

Hepatitis B virus (HBV) surface antigen (HBsAg) is considered to be the most important target for the diagnosis and immune prophylaxis of HBV infection. HBsAg-specific monoclonal antibodies (MAbs) are extensively used for studying the complex structure of the HBsAg, mapping the neutralizing epitopes and development of HBV diagnostic tests.

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Pre-Made Lenvervimab biosimilar, Whole Mab: Anti-HBV therapeutic antibody
Lenvervimab
HBV
Whole mAb
Pre-Made Tuvirumab Biosimilar, Whole Mab: Anti-Hbv (Hepatitis B Virus) [Hepatitis B Virus] therapeutic antibody
tuvirumab
HBV (hepatitis B virus) [Hepatitis B virus]
Whole mAb
Pre-Made Exbivirumab Biosimilar, Whole Mab: Anti-Hbv (Hepatitis B Virus) Surface Antigen (Hbsag) [Hepatitis B Virus] therapeutic antibody
exbivirumab
HBV (hepatitis B virus) surface antigen (HBsAg) [Hepatitis B virus]
Whole mAb
Pre-Made Libivirumab Biosimilar, Whole Mab: Anti-Hbv (Hepatitis B Virus) Surface Antigen (Hbsag) [Hepatitis B Virus] therapeutic antibody
libivirumab
HBV (hepatitis B virus) surface antigen (HBsAg) [Hepatitis B virus]
Whole mAb

4. Rabies virus neutralizing antibodies (NAb)

Rabies virus is the causative agent of the rabies. The Rabies Virus Spike Glycoproteins are the important protein responsible for the virus entry and the major target of neutralizing antibodies. GeneMedi offers the Rabies Virus Spike Glycoprotein G, Rabies Virus Surface Glycoprotein 4 (gp4) Epitope 1, Rabies Virus Strain ERA GP Ectodomain Epitope G-II, Rabies Virus Spike Glycoprotein G, Rabies Virus Strain ERA GP Ectodomain Epitope G-III, RV Antigenic Site III, RV Antigenic Site III-specific monoclonal antibodies (MAbs) for therapeutic application and development of Rabies virus diagnostic tests.

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Pre-Made Docaravimab biosimilar, Whole mAb (Mouse): Anti-Rabies Virus Strain ERA GP Ectodomain Epitope G-III therapeutic antibody
Docaravimab
Rabies Virus Strain ERA GP Ectodomain Epitope G-III
Whole mAb (Mouse)
Pre-Made Foravirumab biosimilar, Whole Mab: Anti-RV Antigenic Site III therapeutic antibody
Foravirumab
RV Antigenic Site III
Whole mAb
Pre-Made Miromavimab biosimilar, Whole mAb (Mouse): Anti-Rabies Virus Strain ERA GP Ectodomain Epitope G-II therapeutic antibody
Miromavimab
Rabies Virus Strain ERA GP Ectodomain Epitope G-II
Whole mAb (Mouse)
Pre-Made Rafivirumab biosimilar, Whole Mab: Anti-RV Antigenic Site III therapeutic antibody
Rafivirumab
RV Antigenic Site III
Whole mAb
Pre-Made Mazorelvimab biosimilar, Whole Mab: Anti-Rabies Virus Spike Glycoprotein G therapeutic antibody
Mazorelvimab
Rabies Virus Spike Glycoprotein G
Whole mAb
Pre-Made Ormutivimab biosimilar, Whole Mab: Anti-Rabies Virus Surface Glycoprotein 4 (gp4) Epitope 1 therapeutic antibody
Ormutivimab
Rabies Virus Surface Glycoprotein 4 (gp4) Epitope 1
Whole mAb
Pre-Made Zamerovimab biosimilar, Whole Mab: Anti-Rabies Virus Spike Glycoprotein G therapeutic antibody
Zamerovimab
Rabies Virus Spike Glycoprotein G
Whole mAb

5. Respiratory syncytial virus (RSV) neutralizing antibodies (NAb)

Respiratory syncytial virus (RSV) enters into the host cells through the type I fusion (F) glycoprotein. Neutralizing monoclonal antibodies, such as Suptavumab, Palivizumab, Nirsevimab, Motavizumab, Gontivimab, and felvizumab target the major antigenic sites on the RSV F glycoprotein and neutralize the entry process.

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Pre-Made Gontivimab biosimilar, Bispecific Single Domains (VH-VH'-VH¡¯): Anti-RSV gpF therapeutic antibody
Gontivimab
RSV gpF
Bispecific Single Domains (VH-VH'-VH¡¯)
Pre-Made Motavizumab biosimilar, Whole Mab: Anti-RSV gpF therapeutic antibody
Motavizumab
RSV gpF
Whole mAb
Pre-Made Nirsevimab biosimilar, Whole Mab: Anti-RSV therapeutic antibody
Nirsevimab
RSV
Whole mAb
Pre-Made Palivizumab biosimilar, Whole Mab: Anti-RSV gpF therapeutic antibody
Palivizumab
RSV gpF
Whole mAb
Pre-Made Suptavumab biosimilar, Whole Mab: Anti-RSV gpF therapeutic antibody
Suptavumab
RSV gpF
Whole mAb
Pre-Made Felvizumab Biosimilar, Whole Mab: Anti-Rsv (Respiratory Syncytial Virus) Glycoprotein F [Respiratory Syncytial Virus] therapeutic antibody
felvizumab
RSV (respiratory syncytial virus) glycoprotein F [Respiratory syncytial virus]
Whole mAb

6. Zaire Ebola virus neutralizing antibodies (NAb)

Zaire Ebola virus belongs to the family Filoviridae, which are highly lethal and it outbreaks since emerging in 1967, including a sustained epidemic in West Africa from 2013 to 2015. Zaire Ebolavirus (EBOV) glycoprotein (GP) is now the key target of antibodies. GP is composed of ectodomain GP1 and a trans-membrane fusion domain GP2. GP1 and GP2 helps the virus to enter host cell through attachment, uptake, and fusion. GeneMedi offers the monoclonal antibodies (MAbs) against Zaire Ebolavirus GP, and Zaire Ebolavirus GP1 for therapeutic application and development of diagnostic tests.

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Pre-Made Ansuvimab biosimilar, Whole Mab: Anti-Zaire Ebolavirus GP1 therapeutic antibody
Ansuvimab
Zaire Ebolavirus GP1
Whole mAb
Pre-Made Atoltivimab biosimilar, Whole Mab: Anti-Zaire Ebolavirus GP therapeutic antibody
Atoltivimab
Zaire Ebolavirus GP
Whole mAb
Pre-Made Cosfroviximab biosimilar, Whole Mab: Anti-Zaire Ebolavirus GP therapeutic antibody
Cosfroviximab
Zaire Ebolavirus GP
Whole mAb
Pre-Made Larcaviximab biosimilar, Whole Mab: Anti-Zaire Ebolavirus GP therapeutic antibody
Larcaviximab
Zaire Ebolavirus GP
Whole mAb
Pre-Made Maftivimab biosimilar, Whole Mab: Anti-Zaire Ebolavirus GP therapeutic antibody
Maftivimab
Zaire Ebolavirus GP
Whole mAb
Pre-Made Odesivimab biosimilar, Whole Mab: Anti-Zaire Ebolavirus GP therapeutic antibody
Odesivimab
Zaire Ebolavirus GP
Whole mAb
Pre-Made Porgaviximab biosimilar, Whole Mab: Anti-Zaire Ebolavirus GP therapeutic antibody
Porgaviximab
Zaire Ebolavirus GP
Whole mAb

7. Influenza virus neutralizing antibodies (NAb)

Influenza is a transmissible acute respiratory disease caused by the influenza virus. The glycoprotein, hemagglutinin (HA) of influenza virus plays an important role during the viral infection. It helps the virus to bind the cell surface receptors, and transfer the genetic materials into the host cytoplasm through fusion. The neutralizing antibodies against the haemagglutinin (HA) offer the protection against influenza virus infection. GeneMedi offers the monoclonal antibodies (MAbs) against Influenza A HA, Influenza B Virus and Influenza A HA2 for therapeutic application and development of diagnostic tests.

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Pre-Made Diridavumab biosimilar, Whole Mab: Anti-Influenza A HA2 therapeutic antibody
Diridavumab
Influenza A HA2
Whole mAb
Pre-Made Firivumab biosimilar, Whole Mab: Anti-Influenza A HA therapeutic antibody
Firivumab
Influenza A HA
Whole mAb
Pre-Made Gedivumab biosimilar, Whole Mab: Anti-Influenza A HA therapeutic antibody
Gedivumab
Influenza A HA
Whole mAb
Pre-Made Lesofavumab biosimilar, Whole Mab: Anti-Influenza B Virus therapeutic antibody
Lesofavumab
Influenza B Virus
Whole mAb
Pre-Made Navivumab biosimilar, Whole Mab: Anti-Influenza A HA therapeutic antibody
Navivumab
Influenza A HA
Whole mAb

8. Human cytomegalovirus (HCMV) neutralizing antibodies (NAb)

Human cytomegalovirus (HCMV) causes life-threatening illness in immunosuppressed patients. HCMV envelope proteins viz. glycoprotein B (gB), gH, gL, gO and UL128/UL130/UL131A are essential for the fusion of virus with the host plasma membranes to enter into the host cell. The gB protein is the direct mediator of cell fusion and it requires gH/gL/gO protein complex for activation. HCMV gB or gH/gL proteins provoke HCMV neutralizing antibodies to prevent the entry of virus into both fibroblasts and epithelial cells. GeneMedi offers the monoclonal antibodies (MAbs) against envelope glycoprotein H (gH) and envelope glycoprotein B (gB) for therapeutic application and development of human cytomegalovirus diagnostic tests.

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Pre-Made Regavirumab Biosimilar, Whole Mab: Anti-Hcmv (Human Cytomegalovirus) Envelope Glycoprotein B (Gb) [Human Betaherpesvirus 5] therapeutic antibody
regavirumab
HCMV (human cytomegalovirus) envelope glycoprotein B (gB) [Human betaherpesvirus 5]
Whole mAb
Pre-Made Sevirumab Biosimilar, Whole Mab: Anti-Hcmv (Human Cytomegalovirus) Envelope Glycoprotein H (Gh) [Human Betaherpesvirus 5] therapeutic antibody
sevirumab
HCMV (human cytomegalovirus) envelope glycoprotein H (gH) [Human betaherpesvirus 5]
Whole mAb

9. Human endogenous retroviral envelope protein HERV-W-Env neutralizing antibodies (NAb)

Temelimab (formerly called GNbAC1) is an immunoglobulin (Ig) G4 monoclonal antibody that targets the human endogenous retroviral envelope protein HERV-W-Env, shown to be associated with the pathogenesis of certain autoimmune disorders such as multiple sclerosis (MS) and type 1 diabetes mellitus (T1D). By neutralizing HERV-W-Env, temelimab could act as a disease-modifying therapy for these disorders. Hence, GeneMedi offers the monoclonal antibodies against MRSV envelope protein for therapeutic application and development of diagnostic tests.

10. Pseudomonas aeruginosa infections neutralizing antibodies (NAb)

Pseudomonas aeruginosa is a main source of health-care related infections, including pneumonia and infections associated with urinary tract, wounds, burns, and the bloodstream.  P. aeruginosa invades the eukaryotic host cells through the type III secretion system (T3SS). This T3SS helps the bacteria to translocate effector proteins directly into host cells. Mammalian immune systems produce neutralizing antibodies (Ab) against T3SS proteins during infection to inhibit the Pseudomonas aeruginosa infections. Hence, GeneMedi offers the different kind of antibodies such as pegylated, Fab, and Bispecific mAb against the PcrV type III secretion system of Pseudomonas aeruginosa.

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Pre-Made Gremubamab biosimilar, Bispecific mAb: Anti-PcrV type III secretion system; Polysaccharide synthesis locus (Pseudomonas) therapeutic antibody
Gremubamab
PcrV type III secretion system,Polysaccharide synthesis locus (Pseudomonas)
Bispecific mAb
Pre-Made Rivabazumab biosimilar, Fab: Anti-PcrV type III secretion system therapeutic antibody
Rivabazumab
PcrV type III secretion system
Fab

11. Measles virus (MeV) neutralizing antibodies (NAb)

Measles virus (MeV) causes an extremely transmissible respiratory disease and it has also been used as an oncolytic platform. MeV enter into the cells through the cellular receptors such as SLAM (signaling lymphocyte-activating molecule) and PVRL4 (poliovirus receptor-like 4) (nectin-4). Hence, the antibodies against PVRL4 could block measles virus infections. GeneMedi offers monoclonal antibodies against the PVRL4 to prevent the MeV infection.

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Pre-Made Enfortumab biosimilar, Whole mAb ADC, Anti-PVRL4/NECTIN4 Antibody: Anti-EDSS1/LNIR/PRR4/nectin-4 therapeutic antibody
Enfortumab
PVRL4
Whole mAb ADC
Pre-Made Enfortumab Vedotin Biosimilar, Whole Mab Adc, Anti-PVRL4/NECTIN4 Antibody: Anti-EDSS1/LNIR/PRR4/nectin-4 therapeutic antibody Drug Conjugate
enfortumab vedotin
PVRL4
Whole mAb ADC

12. Anthrax protective antigen (PA) neutralizing antibodies (NAb)

Bacillus anthracis is the causative agent of anthrax. The protective antigen is an important element of the anthrax toxin. It helps bacteria to transfer the enzymatic components into the host cell, through the formation spanning pore on the membrane. antibiotics are effective at the early stages of anthrax, but antibiotics are no longer effective with the accumulation of anthrax toxin. Therefore, the anti-toxin antibody is the most promising approach to treat the anthrax. GeneMedi offers the monoclonal antibodies (MAbs) against anthrax protective antigen.

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Pre-Made Obiltoxaximab biosimilar, Whole Mab: Anti-Anthrax Protective Antigen therapeutic antibody
Obiltoxaximab
Anthrax Protective Antigen
Whole mAb
Pre-Made Raxibacumab Biosimilar, Whole Mab: Anti-Anthrax Protective Antigen (Pa) [Bacillus Anthracis] therapeutic antibody
raxibacumab
anthrax protective antigen (PA) [Bacillus anthracis]
Whole mAb

13. Shiga toxins (Stxs) neutralizing antibodies (NAb)

Shiga toxins (Stxs) are cytotoxic proteins secreted by Shigella dysenteriae 1 and some serogroups of Escherichia coli (called Stx1 in E. coli). Shiga toxin producing E. coli (STEC) are foodborne pathogens that may colonize and damage the human colon to access to the bloodstream and damage the organs such as kidney and brain. Presently, there are no specific protective treatment against Stx intoxication, and it based on the rehydration therapy, and dialysis. The neutralization of Stx using neutralizing antibody is one of the promising approaches. Therefore, GeneMedi offers monoclonal antibody against Shiga Toxin Type 1 and Type 2.

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Pre-Made Pritoxaximab biosimilar, Whole Mab: Anti-Shiga Toxin Type 1 therapeutic antibody
Pritoxaximab
Shiga Toxin Type 1
Whole mAb
Pre-Made Setoxaximab biosimilar, Whole Mab: Anti-Shiga Toxin Type 2 therapeutic antibody
Setoxaximab
Shiga Toxin Type 2
Whole mAb
Pre-Made Urtoxazumab Biosimilar, Whole Mab: Anti-E.Coli Shiga-Like Toxin 2 B Subunit therapeutic antibody
urtoxazumab
E.coli Shiga-like toxin 2 B subunit
Whole mAb

14. Toxin A neutralizing antibodies (NAb)

Clostridium difficile continues to be one of the most prevalent hospital-acquired bacterial infections in the developed world. Alternative approaches under investigation to combat the anaerobic Gram-positive bacteria include fecal transplantation therapy, vaccines, and antibody-based immunotherapies. Inhibitory antibodies that recognize the primary C. difficilevirulence factors, toxin A and toxin B, are the most popular passive immunotherapies under investigation.

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Pre-Made Actoxumab biosimilar, Whole Mab: Anti-Toxin A therapeutic antibody
Actoxumab
Toxin A
Whole mAb
Pre-Made Atidortoxumab biosimilar, Whole Mab: Anti-Toxin A therapeutic antibody
Atidortoxumab
Toxin A
Whole mAb
Pre-Made Berlimatoxumab biosimilar, Whole Mab: Anti-Toxin A therapeutic antibody
Berlimatoxumab
Toxin A
Whole mAb
Pre-Made Bezlotoxumab biosimilar, Whole Mab: Anti-Toxin A therapeutic antibody
Bezlotoxumab
Toxin A
Whole mAb
Pre-Made Suvratoxumab biosimilar, Whole Mab: Anti-Toxin A therapeutic antibody
Suvratoxumab
Toxin A
Whole mAb
Pre-Made Tosatoxumab biosimilar, Whole Mab: Anti-Toxin A therapeutic antibody
Tosatoxumab
Toxin A
Whole mAb

15. Others neutralizing antibodies (NAb)

Monoclonal antibodies (mAbs) against bacterial infections are more effective way to treat the antibiotic resistant strains. The antibacterial mAbs have several advantages such as reducing the antibiotic toxicity, treatment time and disease complications. there are numerous mAb products are under development for a range of infectious diseases. Currently, GeneMedi offers mAbs against gram negative bacteria, Staphylococcus epidermidis, Staphylococcus aureus and so on.

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Pre-Made Bentracimab biosimilar, Whole Mab: Anti-AR-C124910XX therapeutic antibody
Bentracimab
AR-C124910XX
Whole mAb
Pre-Made Omodenbamab biosimilar, Whole Mab: Anti-SpA therapeutic antibody
Omodenbamab
SpA
Whole mAb
Pre-Made Panobacumab biosimilar, Whole Mab: Anti-Serotype IATS O11 therapeutic antibody
Panobacumab
Serotype IATS O11
Whole mAb
Pre-Made Tefibazumab Biosimilar, Whole Mab: Anti-Staphylococcus Aureus Fibrin-Binding Surface Epitope Clumping Factor A (Clfa) therapeutic antibody
tefibazumab
Staphylococcus aureus fibrin-binding surface epitope clumping factor A (ClfA)
Whole mAb
Pre-Made Edobacomab Biosimilar, Whole Mab: Anti-Endotoxin (Lipid A, Domain Of Lipopolyaccharide, Lps) [Gram Negative Bacteria] therapeutic antibody
edobacomab
endotoxin (lipid A, domain of lipopolyaccharide, LPS) [gram negative bacteria]
Whole mAb
Pre-Made Nebacumab Biosimilar, Whole Mab: Anti-Endotoxin (Lipid A, Domain Of Lipopolyaccharide, Lps) [Gram Negative Bacteria] therapeutic antibody
nebacumab
endotoxin (lipid A, domain of lipopolyaccharide, LPS) [gram negative bacteria]
Whole mAb
Pre-Made Pagibaximab Biosimilar, Whole Mab: Anti-Staphylococcus Epidermidis Lipoteichoic Acid therapeutic antibody
pagibaximab
Staphylococcus epidermidis lipoteichoic acid
Whole mAb