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ITGA4: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It’s the GeneMedi’s summary page for Target/Biomarker Introduction of ITGA4. The page also collects GeneMedi’s different modalities and formats products for ITGA4 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi’s target-insight database-GM ITD database, the ITGA4 target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Transmembrane Protein.
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn’s disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
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Target ID |
GM-T97587
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Target Name |
ITGA4
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Gene ID |
3676
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Gene Official Name |
ITGA4
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Gene Alias |
CD49D, IA4
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Protein Sub-location |
Transmembrane Protein
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Category |
Therapeutics Target, Immuno-oncology Target, INN Index
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Pre-made ITGA4-specific INN-index biosimilar (antibody&conjugates)-Vedolizumab, Etrolizumab, Abrilumab, Natalizumab
Anti-ITGA4 therapeutic INN-index antibodies and conjugates are biosimilars expressed by mammalian cell line as a benchmark reference therapeutic antibody for drug discovery, target MOA research, cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
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Cat No. | Products Name (INN Index) | INN Name | Previous Name | Target | Format | Order |
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Pre-Made Abrilumab biosimilar, Whole mAb, Anti-¦Á4¦Â7/Integrin alpha 4 beta 7 Antibody: Anti-LPAM?1 therapeutic antibody |
Abrilumab |
NA |
α4β7/Integrin alpha 4 beta 7 |
Whole mAb |
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Pre-Made Etrolizumab biosimilar, Whole Mab: Anti-ITGA4;ITGB7;ITGAE;ITGB7 therapeutic antibody |
Etrolizumab |
NA |
ITGA4_ITGB7&ITGAE_ITGB7 |
Whole mAb |
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Pre-Made Natalizumab biosimilar, Whole mAb, Anti-ITGA4 Antibody: Anti-CD49D/IA4 therapeutic antibody |
Natalizumab |
NA |
ITGA4 |
Whole mAb |
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Pre-Made Vedolizumab biosimilar, Whole mAb, Anti-ITGA4;ITGB7 Antibody: Anti-CD49D/IA4 therapeutic antibody |
Vedolizumab |
NA |
ITGA4_ITGB7 |
Whole mAb |
Anti-ITA4/ ITGA4/ CD49D antibody for FACS & in-vivo assay| GMab
Pre-made anti-ITGA4 benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-ITGA4 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
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Cat No. | Antibody Name | Format | Classified by tag | Order
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|---|---|---|---|---|
Anti-ITGA4 monoclonal antibody |
mab |
FACS/Biofunctional Antibody, Therapeutics Target antibody |
