Pre-made Vedolizumab benchmark antibody (Whole mAb, anti-ITGA4;ITGB7 therapeutic antibody, Anti-CD49D/IA4 Antibody) is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Vedolizumab, sold under the brand name Entyvio, is a monoclonal antibody medication developed by Millennium Pharmaceuticals, Inc (currently named Takeda Oncology, a subsidiary of Takeda Pharmaceuticals) for the treatment of ulcerative colitis and Crohn’s disease. It binds to integrin ¦Á4¦Â7 (LPAM-1, lymphocyte Peyer’s patch adhesion molecule 1, a dimer of Integrin alpha-4 and Integrin beta-7). Blocking the ¦Á4¦Â7 integrin results in gut-selective anti-inflammatory activity. It is marketed under the trade name Entyvio.