Pre-made Vedolizumab benchmark antibody ( Whole mAb, anti-ITGA4;ITGB7 therapeutic antibody, Anti-CD49D/IA4 Antibody) for drug discovery and mechanism of action (MOA) research

Cat:GMP-Bios-ab-616

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SKU GMP-Bios-ab-616 Category Tag

Product Details

Pre-made Vedolizumab benchmark antibody (Whole mAb, anti-ITGA4;ITGB7 therapeutic antibody, Anti-CD49D/IA4 Antibody) is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Vedolizumab, sold under the brand name Entyvio, is a monoclonal antibody medication developed by Millennium Pharmaceuticals, Inc (currently named Takeda Oncology, a subsidiary of Takeda Pharmaceuticals) for the treatment of ulcerative colitis and Crohn’s disease. It binds to integrin ¦Á4¦Â7 (LPAM-1, lymphocyte Peyer’s patch adhesion molecule 1, a dimer of Integrin alpha-4 and Integrin beta-7). Blocking the ¦Á4¦Â7 integrin results in gut-selective anti-inflammatory activity. It is marketed under the trade name Entyvio.

Products Name (INN Index)

Pre-Made Vedolizumab biosimilar, Whole mAb, Anti-ITGA4;ITGB7 Antibody: Anti-CD49D/IA4 therapeutic antibody

INN Name

Vedolizumab

Target

ITGA4_ITGB7

Format

Whole mAb

Derivation

Humanized

Species Reactivity

Human

CH1 Isotype

IgG1

VD LC

Kappa

Highest_Clin_Trial (Jan '20)

Approved

Est. Status

Active

100% SI Structure

None

99% SI Structure

None

95-98% SI Structure

None

Year Proposed

2008

Companies

Medical College of Wisconsin,Millennium Pharmaceuticals,Takeda,Takeda Oncology

Conditions Approved

Crohn's disease,Ulcerative colitis

Conditions Active

Graft-versus-host disease,Coeliac disease

Conditions Discontinued

Malignant melanoma

Development Tech

NA

Previous Name

NA

Gm Offical Target Name

ITGA4_ITGB7

Package

, ,

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