Diagnostic Cardiac troponin I (cTnI) antibodies?(anti-Cardiac troponin I,?anti-cTnI)?and?diagnostic?recombinantCardiac troponin I (cTnI) )?antigens?(recombinantCardiac troponin I (cTnI) ?protein)?forCardiovascular Disease cTnI?detection?in?ELISA?test,Lateral?flow?immunoassay?(LFIA), colloidal?gold?immunochromatographic?assay,?Chemiluminescent?immunoassay?(CLIA), turbidimetric?inhibition?immuno?assay?(TINIA), immunonephelometry?and?POCT.
Product Details
Cardiac troponin I, often denoted as cTnI, is presented in cardiac muscle tissue by a single isoform with a molecular weight of 23.9 kDa. It consists of 209 amino acid residues. The theoretical pI of cTnI is 9.05.[3]?cTnI differs from other troponins due to its N-terminal extension of 26 amino acids. This extension contains two serines, residues 23 and 24, which are phosphorylated by?protein kinase A?in response to beta-adrenergic stimulation and important in increasing the inotropic response.[4]?Phosphorylation of cTnI changes the conformation of the protein and modifies its interaction with other troponins as well as the interaction with anti-TnI antibodies. These changes alter the myofilament response to calcium, and are of interest in targeting heart failure. Multiple reaction monitoring of human cTnI has revealed that there are 14 phosphorylation sites and the pattern of phosphorylation observed these sites is changed in response to disease.[5]?cTnI has been shown to be phosphorylated by protein kinase A,?protein kinase C,?protein kinase G, and?p21-activated kinase 3.[6]?A significant part of cTnI released into the patient’s blood stream is phosphorylated.[7]?For more than 15 years cTnI has been known as a reliable marker of cardiac muscle tissue injury. It is considered to be more sensitive and significantly more specific in diagnosis of the myocardial infarction than the “golden?marker” of last decades –?CK-MB, as well as total?creatine kinase,?myoglobin?and?lactate dehydrogenase?isoenzymes.Genemedi produces core diagnostic ingredients for test of Cardiovascular Disease and related syndrome.
GeneMedi offers paired diagnostics grade ?cardiac troponin I (cTnI) ) antibodies (monoclonal antibody, mab) and ?cardiac troponin I (cTnI) ) antigens for Cardiovascular Disease rapid test kit of ?cardiac troponin I (cTnI) ) testing in ELISA test,Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT.
All the antibodies and antigens for Cardiovascular Disease test are suitable for in functional ELISA, and other immunoassays in dignostics.The antibodies can act as a capture antibody and detection antibody.The antigens can be used for antibodies rapid test of Cardiovascular Disease.
Product Description
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Antigen & Antibody Name
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Anti-human Human cTnI mouse monoclonal antibody (mAb)
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Expression platform
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Hybridoma
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Isotypes
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Mouse IgG
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Bioactivity validation
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Human Cardiac troponin I (cTnI) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other Cardiac troponin I (cTnI) antibodies in cTnI level test of Cardiovascular disease ( myocardial infarction ) and related syndrome evaluation.
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Tag
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mFc
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Products description
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Anti-human Human cTnI mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by hybridoma technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other Cardiac troponin I (cTnI) antibodies.
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Purity
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Purity: ≥95% (SDS-PAGE)
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Application
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ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT
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Formulation
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Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
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Storage
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Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.
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Cat No.
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GMP-cTnI-Ag-Ab
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Product Name
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Recombinant human Human cTnI Protein
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Expression platform
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E.coli
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Isotypes
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Recombinant Antigen
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Bioactivity validation
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Cardiac troponin I (cTnI) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in cTnI level test of Cardiovascular disease ( myocardial infarction ) and related syndrome evaluation
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Tag
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His
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Products description
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Recombinant human Human cTnI Protein was expressed in E.coli -based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
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Purity
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Purity: ≥95% (SDS-PAGE)
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Application
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Standard substance, positive control, ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA),immunonephelometry and POCT.
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Formulation
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Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
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Storage
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Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.
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Diagnostic antibodies and antigens for infectious disease testing including HIV/AIDS, HCV, Influenza A/B, Syphilis, Helicobacter pylori, HSV-1/2, CMV, rubella virus, toxoplasma.
Cytokine release syndrome (CRS) is an acute systemic inflammatory syndrome characterized by fever and multiple organ dysfunction.
Genemedi produces core diagnostic ingredients for test of infectious diseases and related syndrome.
GeneMedi offers paired diagnostics grade antibodies (monoclonal antibody,mab)and antigens for infectious disease rapid test kit including infection of HIV/AIDS,Hepatitis C virus(HCV), Influenza A/B,Treponema Pallidum caused Syphilis,Helicobacter pylori (H. pylori) Bacteria, Herpes simplex virus 1/2(HSV-1/HSV-2),Cytomegalovirus (CMV),rubella virus,toxoplasma gondii and so on.
All the antibodies of inflammation and CRS test are suitable for in functional ELISA, and other immunoassays in dignostics. The antibody can act as a capture antibody and detection antibody.
