human APH1A Lentivirus plasmid
Cat:pGMLP002425
If you purchase ORF/cDNA clone-Lentivirus plasmid, ORF vector will be delivered with P-ALV-B11 backbone together.
Availability:3-7 business days

Description
Catalog ID
pGMLP002425
Gene Name
APH1A
Product Name
human APH1A Lentivirus plasmid
Accession Number
NM_001077628
Gene ID
51107
Species
human
Product Type
Lentivirus plasmid
Insert Length
798
Gene Alias
6530402N02Rik;APH-1;APH-1A;CGI-78
Fluorescent Label
GFP+PURO
Fusion Tag
3×flag
Promoter
CMV
Resistance
Amplicin
gene description
This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer’s disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq, Aug 2011]
Maker
GFP+PURO
Regulation
overexpression