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PDGFRA: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It’s the GeneMedi’s summary page for Target/Biomarker Introduction of PDGFRA. The page also collects GeneMedi’s different modalities and formats products for PDGFRA in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi’s target-insight database-GM ITD database, the PDGFRA target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Transmembrane Protein.
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]
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Target ID |
GM-T53524
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Target Name |
PDGFRA
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Gene ID |
5156
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Gene Official Name |
PDGFRA
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Gene Alias |
CD140A, PDGFR-2, PDGFR2
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Protein Sub-location |
Transmembrane Protein
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Category |
Therapeutics Target, INN Index, Cytokine
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Pre-made PDGFRA-specific INN-index biosimilar (antibody&conjugates)-Olaratumab, Tovetumab
Anti-PDGFRA therapeutic INN-index antibodies and conjugates are biosimilars expressed by mammalian cell line as a benchmark reference therapeutic antibody for drug discovery, target MOA research, cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
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Cat No. | Products Name (INN Index) | INN Name | Previous Name | Target | Format | Order |
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Pre-Made Olaratumab biosimilar, Whole mAb, Anti-PDGFRA Antibody: Anti-CD140A/PDGFR-2/PDGFR2 therapeutic antibody |
Olaratumab |
NA |
PDGFRA |
Whole mAb |
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Pre-Made Tovetumab biosimilar, Whole mAb, Anti-PDGFRA Antibody: Anti-CD140A/PDGFR-2/PDGFR2 therapeutic antibody |
Tovetumab |
NA |
PDGFRA |
Whole mAb |
Anti-PGFRA/ PDGFRA/ CD140A antibody for FACS & in-vivo assay| GMab
Pre-made anti-PDGFRA benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-PDGFRA mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
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Cat No. | Antibody Name | Format | Classified by tag | Order
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|---|---|---|---|---|
Anti-PDGFRA monoclonal antibody |
mab |
FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
