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human, Cynomolgus/ Rhesus macaque, rat, mouse ciliary neurotrophic factor (CNTF) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.
Cat:GM-Tg-hg-T83192-Ag-1
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Description
Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse ciliary neurotrophic factor (CNTF) His+Avi (Biotinylated) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Ciliary neurotrophic factor is a protein that in humans is encoded by the CNTF gene.
The protein encoded by this gene is a polypeptide hormone and neurotrophic factor whose actions have mainly been studied in the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neural populations including astrocytes. It is a hypothalamic neuropeptide that is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. In addition to the predominant monocistronic transcript originating from this locus, the gene is also cotranscribed with the upstream ZFP91 gene. Cotranscription from the two loci results in a transcript that contains a complete coding region for the zinc finger protein but lacks a complete coding region for ciliary neurotrophic factor.
CNTF has also been shown to be expressed by cells on the bone surface, and to reduce the activity of bone-forming cells (osteoblasts).
Target Information
Target Name
CNTF
Full name
ciliary neurotrophic factor
Gene ID
https://www.ncbi.nlm.nih.gov/gene/?term=1270
Gene Name
CNTF
Gene Alias
HCNTF
Protein Sub-location
Introcelluar Protein
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Antigen Information
Cat No.
GM-Tg-hg-T83192-Ag-1,GM-Tg-rg-T83192-Ag-1,GM-Tg-mg-T83192-Ag-1,GM-Tg-cynog-T83192-Ag-1
Product Name
ciliary neurotrophic factor (CNTF) protein
Species
human, Cynomolgus/ Rhesus macaque, rat, mouse
Isotypes
Recombinant protein
Expression platform
Mammalian cell
Bioactivity validation
Affintiy&bioactivity validated by ELISA, cell culture validated
Tag
His
Product Description
Recombinant human, Cynomolgus/ Rhesus macaque, rat, mouse ciliary neurotrophic factor (CNTF) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity
Purity: ≥95% (SDS-PAGE)
Application
Formulation
Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage
Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.
Antibody Information
Catalog No.
GM-Tg-hg-T83192-Ab-1, GM-Tg-hg-T83192-Ab-2, GM-Tg-rg-T83192-Ab-1, GM-Tg-rg-T83192-Ab-2, GM-Tg-mg-T83192-Ab-1, GM-Tg-mg-T83192-Ab-2, GM-Tg-cynog-T83192-Ab-1, GM-Tg-cynog-T83192-Ab-2
Product Name
Anti-CNTF monoclonal antibody
Format
mab
Category of antibody
Therapeutics Target antibody, Cytokine antibody
Derivation (species)
Mouse
Species Reactivity
CH1+2+3 Isotype (Receptor identification)
IgG
Type of Light Chain (VD-LC)
N/A
Expression platform
Mammalian Expression
Bioactivity validation
Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
Tag
Fc
Products description
Pre-made anti-CNTF monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity
Purity: ≥95% (SDS-PAGE)
Application
Biological drug discovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation
Lyophilized from sterile PBS, PH 7.4
Storage
Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.
Cytokines and Growth Factors-GeneMedi Descrition: An Lanscape of Cytokines & Growth Factors, including family classification, functional and reagent products list
Cytokines are small cell-signaling proteins that are secreted by numerous cell types (some of the cytokines are transmembrane proteins). Importantly, most cytokines function in their local microenvironment, rather than in a systemic manner. Cytokines bind to specific cell surface receptors, thereby activating intracellular signaling cascades that involve phosphorylation events that ultimately result in gene transcription. They are crucial to innate and adaptive inflammatory responses, cell growth and differentiation, cell death, angiogenesis and developmental as well as repair processes. Because of their involvement in immune and inflammatory responses, cytokines hold promise as therapeutic targets.
GeneMedi (GM) has plentiful expertise and experience in cytokines & growth factors product development and manufacturing. GM provides various cytokines for applications such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis. The classification of the cytokines includes adipokine, TNF superfamily, VEGF family, chemokines and chemokine receptors, IL-1 family, IL-6 family, IL-10 family, IL-12 family, IL-17 family, activins family, SMAD family, BMP family, IGF family, FGF family, WNT family, GDF family, EGF family, interferons (IFNS) family, NOTCH family, PDGF family, TGF-BETA family, and GDNF family.
Most of GM’s cell-culture grade cytokines and growth factors products are validated and highly evaluated by global researchers both in academia and industry.
