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Pre-Made Ramatercept Biosimilar, Fusion Protein targeting MSTN/GDF-8 fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting GDF8/MSLHP for drug discovery and mechanism of action (MOA) research
Cat:GMP-Bios-INN-967
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Product Details
Pre-Made Ramatercept Biosimilar, Fusion Protein targeting MSTN/GDF-8 fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting GDF8/MSLHP is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Ramatercept is a fusion protein of activin receptor type IIB and IgG1-Fc, which binds myostatin and related ligands. It aims to disrupt the inhibitory effect on muscle development and provide potential therapy for myopathies like Duchenne muscular dystrophy (DMD).
| Products Name (INN Index) | Pre-Made Ramatercept Biosimilar, Fusion Protein targeting MSTN/GDF-8 fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting GDF8/MSLHP |
|---|---|
| INN Name | ramatercept |
| Target | MSTN |
| Format | Fusion Protein |
| Derivation | Human |
| Species Reactivity | Human |
| CH1 Isotype | Fusion – [ACVR2B (activin A receptor type IIB, ActR-IIB, ActRIIB)]2 – IGHG1 Fc (Fragment constant) |
| VD LC | Fusion – [ACVR2B (activin A receptor type IIB, ActR-IIB, ActRIIB)]2 – IGHG1 Fc (Fragment constant) |
| Highest_Clin_Trial (Jan '20) | NA |
| Est. Status | NA |
| 100% SI Structure | NA |
| 99% SI Structure | NA |
| 95-98% SI Structure | NA |
| Year Proposed | NA |
| Year Recommended | NA |
| Companies | Acceleron?Pharma, Inc (Cambridge UK) |
| Conditions Approved | NA |
| Conditions Active | NA |
| Conditions Discontinued | NA |
| Development Tech | NA |
| Previous Name | NA |
| Gm Offical Target Name | MSTN |
| Package |
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