Pre-Made Eftansomatropin Alfa Biosimilar, Fusion Protein targeting GHR fused with human IGHG4 Fc (Fragment constant): Recombinant therapeutic protein targeting GHBP/GHIP for drug discovery and mechanism of action (MOA) research

Cat:GMP-Bios-INN-827

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SKU GMP-Bios-INN-827 Category Tag

Product Details

Pre-Made Eftansomatropin Alfa Biosimilar, Fusion Protein targeting GHR fused with human IGHG4 Fc (Fragment constant): Recombinant therapeutic protein targeting GHBP/GHIP is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Eftansomatropin alfa is a potential highly differentiated long-acting recombinant human growth hormone being developed as a more convenient and effective therapy for growth hormone deficiency (GHD). Eftansomatropin alfa contains hGH-hyFc (GX-H9) which is a recombinant human growth hormone prepared by fusing hybrid Fc to human growth hormone hGH. Like endogenous growth hormone, eftansomatropin alfa stimulates the production of insulin-like growth factor 1 (IGF-1) in the liver, which has growth-stimulating effects on a variety of tissues, including osteoblast and chondrocyte activities that stimulate bone growth.

Products Name (INN Index)

Pre-Made Eftansomatropin Alfa Biosimilar, Fusion Protein targeting GHR fused with human IGHG4 Fc (Fragment constant): Recombinant therapeutic protein targeting GHBP/GHIP

INN Name

eftansomatropin alfa

Target

GHR

Format

Fusion Protein

Derivation

Human

Species Reactivity

Human

CH1 Isotype

Fusion – [GH1 (growth hormone 1, somatotropin, GH, GH-N, GHN, hGH- N, pituitary growth hormone)]1 – IGHG4 Fc (Fragment constant)

VD LC

Fusion – [GH1 (growth hormone 1, somatotropin, GH, GH-N, GHN, hGH- N, pituitary growth hormone)]1 – IGHG4 Fc (Fragment constant)

Highest_Clin_Trial (Jan '20)

NA

Est. Status

NA

100% SI Structure

NA

99% SI Structure

NA

95-98% SI Structure

NA

Year Proposed

NA

Companies

Genexine (Seongnam South Korea)

Conditions Approved

NA

Conditions Active

NA

Conditions Discontinued

NA

Development Tech

NA

Previous Name

NA

Gm Offical Target Name

GHR

Package

, ,

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