Pre-Made Efbemalenograstim Alfa Biosimilar, Fusion Protein targeting CSF3R/G-CSF-R fused with human IGHG2 Fc (Fragment constant) via a peptidyl linker: Recombinant therapeutic protein targeting CD114/GCSFR/SCN7 for drug discovery and mechanism of action (MOA) research
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Product Details
Pre-Made Efbemalenograstim Alfa Biosimilar, Fusion Protein targeting CSF3R/G-CSF-R fused with human IGHG2 Fc (Fragment constant) via a peptidyl linker: Recombinant therapeutic protein targeting CD114/GCSFR/SCN7 is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Efbemalenograstim Alfa contains a recombinant fusion protein containing G-CSF at the amino terminal and human IgG2-Fc fragment at the carboxyl terminal. It is used to treat chemotherapy-induced neutropenia (CIN) in breast cancer patients.
| Products Name (INN Index) | Pre-Made Efbemalenograstim Alfa Biosimilar, Fusion Protein targeting CSF3R/G-CSF-R fused with human IGHG2 Fc (Fragment constant) via a peptidyl linker: Recombinant therapeutic protein targeting CD114 |
|---|---|
| INN Name | efbemalenograstim alfa |
| Target | CSF3R |
| Format | Fusion Protein |
| Derivation | Human |
| Species Reactivity | Human |
| CH1 Isotype | Fusion – [CSF3 (colony stimulating factor 3, GCSF, granulocyte colony- stimulating factor, G-CSF)]2 – IGHG2 |
| VD LC | Fusion – [CSF3 (colony stimulating factor 3, GCSF, granulocyte colony- stimulating factor, G-CSF)]2 – IGHG2 |
| Highest_Clin_Trial (Jan '20) | NA |
| Est. Status | NA |
| 100% SI Structure | NA |
| 99% SI Structure | NA |
| 95-98% SI Structure | NA |
| Year Proposed | NA |
| Year Recommended | NA |
| Companies | Generon Corporation (Shanghai)?Ltd. (Shanghai China) |
| Conditions Approved | NA |
| Conditions Active | NA |
| Conditions Discontinued | NA |
| Development Tech | NA |
| Previous Name | NA |
| Gm Offical Target Name | CSF3R |
| Package |
