Pre-made Indusatumab benchmark antibody ( Whole mAb ADC, anti-GUCY2C therapeutic antibody, Anti-DIAR6/GC-C/GUC2C/MECILIL/STAR Antibody) for drug discovery and mechanism of action (MOA) research

Cat:GMP-Bios-ab-272

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SKU GMP-Bios-ab-272 Category Tag

Product Details

Pre-Made Indusatumab biosimilar, Whole mAb ADC, Anti-GUCY2C Antibody: Anti-DIAR6/GC-C/GUC2C/MECILIL/STAR therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Indusatumab vedotin (MLN-0264) is an antibody-drug conjugate that is under development for the treatment of pancreatic cancer and other gastrointestinal cancers. It consists of a monoclonal antibody (indusatumab) that targets the enzyme guanylate cyclase 2C which is present in some cancers, linked to an average of three to four molecules of the chemotherapeutic agent monomethyl auristatin E (MMAE).

Products Name (INN Index)

Pre-Made Indusatumab biosimilar, Whole mAb ADC, Anti-GUCY2C Antibody: Anti-DIAR6/GC-C/GUC2C/MECILIL/STAR therapeutic antibody

INN Name

Indusatumab

Target

GUCY2C

Format

Whole mAb ADC

Derivation

Human

Species Reactivity

Human

CH1 Isotype

IgG1

VD LC

Kappa

Highest_Clin_Trial (Jan '20)

Phase-II

Est. Status

Discontinued

100% SI Structure

None

99% SI Structure

None

95-98% SI Structure

None

Year Proposed

2014

Companies

Millennium,Takeda Oncology

Conditions Approved

NA

Conditions Active

NA

Conditions Discontinued

Colorectal cancer,Gastrointestinal cancer,Pancreatic cancer

Development Tech

NA

Previous Name

NA

Gm Offical Target Name

GUCY2C

Package

, ,

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