Pre-made Cetuximab benchmark antibody ( Whole mAb, anti-EGFR therapeutic antibody, Anti-ERBB/ERRP/HER1/mENA/ERBB1/PIG61/NISBD2 Antibody) for drug discovery and mechanism of action (MOA) research

Cat:GMP-Bios-ab-102

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SKU GMP-Bios-ab-102 Category Tag

Product Details

Pre-Made Cetuximab biosimilar, Whole mAb, Anti-EGFR Antibody: Anti-ERBB/ERRP/HER1/mENA/ERBB1/PIG61/NISBD2 therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Cetuximab is an epidermal growth factor receptor (EGFR) inhibitor medication used for the treatment of metastatic colorectal cancer and head and neck cancer. Cetuximab is a chimeric (mouse/human) monoclonal antibody given by intravenous infusion that is distributed under the trade name Erbitux in the U.S. and Canada by the drug company Eli Lilly and Co. and outside those countries by the drug company Merck KGaA. In Japan, Merck KGaA, Bristol-Myers Squibb and Eli Lilly have a co-distribution.

Products Name (INN Index)

Pre-Made Cetuximab biosimilar, Whole mAb, Anti-EGFR Antibody: Anti-ERBB/ERRP/HER1/mENA/ERBB1/PIG61/NISBD2 therapeutic antibody

INN Name

Cetuximab

Target

EGFR

Format

Whole mAb

Derivation

Chimeric (Mouse/Human)

Species Reactivity

Human

CH1 Isotype

IgG1

VD LC

Kappa

Highest_Clin_Trial (Jan '20)

Approved

Est. Status

Active

100% SI Structure

6au5:DC:BA/6axp:BA:DC/6ayn:BA:DC/6azk:DC:BA/6azl:BA:DC

99% SI Structure

5i76:DC:BA/1yy8:DC:BA/5th2:DC:BA/5f88:DC:BA/5hyq:DC:BA/5ir1:DC:BA/5ivz:DC:BA/5iv2:DC:BA/5t1k:DC:BA/5t1l:DC:BA/5id0:DC:BA/5id1:DC:BA/5euk:DC:BA/5ff6:DC:BA/5iop:DC:BA/5icy:DC:BA/5itf:DC:BA/5etu:DC:BA/5

95-98% SI Structure

5gz0:BA:DC/6arp:BA:DC/6aru:CB

Year Proposed

1999

Companies

Array BioPharma,Bristol-Myers Squibb,Celldex Therapeutics Inc,Centre Jean Perrin,Eli Lilly,Merck KGaA,New York University School of Medicine,Novartis,Pierre Fabre,Roche,University Hospital Ghent,Univ

Conditions Approved

Colorectal cancer,Head and neck cancer

Conditions Active

Non-small cell lung cancer,Bladder cancer,Breast cancer,Gastric cancer,Mesothelioma,Rectal cancer,Squamous cell cancer,Adenoid cystic carcinoma,Oesophageal cancer

Conditions Discontinued

Pancreatic cancer,Prostate cancer

Development Tech

NA

Previous Name

NA

Gm Offical Target Name

EGFR

Package

, ,

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