Pre-made Bevacizumab benchmark antibody ( Whole mAb, anti-VEGFA therapeutic antibody, Anti-VPF/VEGF/MVCD1 Antibody) for drug discovery and mechanism of action (MOA) research

Cat:GMP-Bios-ab-065

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SKU GMP-Bios-ab-065 Category Tag

Product Details

Pre-Made Bevacizumab biosimilar, Whole mAb, Anti-VEGFA Antibody: Anti-VPF/VEGF/MVCD1 therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Bevacizumab, sold under the brand name Avastin, is a medication used to treat a number of types of cancers and a specific eye disease. For cancer, it is given by slow injection into a vein (intravenous) and used for colon cancer, lung cancer, glioblastoma, and renal-cell carcinoma. In many of these diseases it is used as a first-line therapy. For age-related macular degeneration it is given by injection into the eye (intravitreal).

Products Name (INN Index)

Pre-Made Bevacizumab biosimilar, Whole mAb, Anti-VEGFA Antibody: Anti-VPF/VEGF/MVCD1 therapeutic antibody

INN Name

Bevacizumab

Target

VEGFA

Format

Whole mAb

Derivation

Humanized

Species Reactivity

Human

CH1 Isotype

IgG1

VD LC

Kappa

Highest_Clin_Trial (Jan '20)

Approved

Est. Status

Active

100% SI Structure

1bj1:HL:KJ

99% SI Structure

None

95-98% SI Structure

6bft:AB:HL/1cz8:HL:YX

Year Proposed

2000

Conditions Approved

Breast cancer,Cervical cancer,Colorectal cancer,Glioblastoma,Glioma,Non-small cell lung cancer,Ovarian cancer,Renal cell carcinoma,Fallopian tube cancer,Peritoneal cancer

Conditions Active

Head and neck cancer,Biliary cancer,Brain metastases,Endometrial cancer,Ewing's sarcoma,Gynaecological cancer,Hodgkin's disease,Intestinal cancer,Liver cancer,Liver metastases,Malignant melanoma,Meni

Conditions Discontinued

Carcinoid tumour,Chronic lymphocytic leukaemia,Diffuse large B cell lymphoma,Eye disorders,Gastric cancer,Gastrointestinal stromal tumours,Mesothelioma,Oesophageal cancer,Pancreatic cancer,Prostate c

Development Tech

NA

Previous Name

NA

Gm Offical Target Name

VEGFA

Package

, ,

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