Diagnostic recombinant neurofilament light chain (NFL) antigens (recombinant neurofilament light chain (NFL) ) protein) for Neuropathy NFL detection in positive control, ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT.
Product Details
Neurofilaments are cytoskeletal components of neurons that are particularly abundant in axons. Their functions include provision of structural support and maintaining size, shape, and caliber of the axons (1). Neurofilaments belong to the intermediate filaments family, and the triplet comprises three subunits; neurofilament light chain (NF-L), neurofilament medium (NF-M) and neurofilament heavy (NF-H). The nomenclature-light (~68 kDa), -medium (~145 kDa),- and heavy (~200 kDa) refers to the molecular weight of the filaments (2, 3).
Following axonal damage in the central nervous system (CNS), neurofilament proteins released into cerebrospinal fluid (CSF) provide an indication of axonal damage and neuronal death. The most extensively subtype studied in this context is NF-L.
Given that neurofilaments are found in the cytoplasm of neurons, all diseases that lead to neuronal and axonal damage can increase the CSF-levels of these proteins. In animal studies, NF-L levels have been used as a marker of axonal damage for decades . In humans, neurofilaments were used as markers of neuronal damage in amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease (AD). Genemedi produces core diagnostic ingredients for test of Neuropathy and related syndrome. GeneMedi offers paired diagnostics grade neurofilament light chain (NFL) antibodies (monoclonal antibody, mab) and neurofilament light chain (NFL) antigens for Neuropathy rapid test kit of neurofilament light chain (NFL) testing in positive control, ELISA test,Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT.All the antibodies and antigens for Neuropathy test are suitable for in functional ELISA, and other immunoassays in dignostics. The antibodies can act as a capture antibody and detection antibody. The antigens can be used for antibodies rapid test of Neuropathy.
Product Description
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Antigen & Antibody Name
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Expression platform
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Isotypes
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Bioactivity validation
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Tag
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Products description
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Purity
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Formulation
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Cat No.
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GMP-NFL-Ag
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Product Name
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Recombinant human Human NFL Protein
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Expression platform
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E.coli
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Isotypes
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Recombinant Antigen
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Bioactivity validation
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neurofilament light chain (NFL) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in NFL level test of Neurodegenerative diseases (Alzheimer Disease(AD)) and related syndrome evaluation
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Tag
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His
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Products description
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Recombinant human Human NFL Protein was expressed in E.coli -based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
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Purity
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Purity: ≥95% (SDS-PAGE)
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Application
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Standard substance, positive control, ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA),immunonephelometry and POCT.
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Formulation
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Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
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Storage
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Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.
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Diagnostic antibodies and antigens for infectious disease testing including HIV/AIDS, HCV, Influenza A/B, Syphilis, Helicobacter pylori, HSV-1/2, CMV, rubella virus, toxoplasma.
Cytokine release syndrome (CRS) is an acute systemic inflammatory syndrome characterized by fever and multiple organ dysfunction.
Genemedi produces core diagnostic ingredients for test of infectious diseases and related syndrome.
GeneMedi offers paired diagnostics grade antibodies (monoclonal antibody,mab)and antigens for infectious disease rapid test kit including infection of HIV/AIDS,Hepatitis C virus(HCV), Influenza A/B,Treponema Pallidum caused Syphilis,Helicobacter pylori (H. pylori) Bacteria, Herpes simplex virus 1/2(HSV-1/HSV-2),Cytomegalovirus (CMV),rubella virus,toxoplasma gondii and so on.
All the antibodies of inflammation and CRS test are suitable for in functional ELISA, and other immunoassays in dignostics. The antibody can act as a capture antibody and detection antibody.
