human CXCR6 Lentivirus plasmid

Cat:pGMLP002468
If you purchase ORF/cDNA clone-Lentivirus plasmid, ORF vector will be delivered with P-ALV-B11 backbone together.
SKU pGMLP002468 Categories , , , Tag

Availability:3-7 business days

Description

Catalog ID

pGMLP002468

Gene Name

CXCR6

Product Name

human CXCR6 Lentivirus plasmid

Accession Number

NM_006564

Gene ID

10663

Species

human

Product Type

Lentivirus plasmid

Insert Length

1029

Gene Alias

BONZO;CD186;STRL33;TYMSTR

Fluorescent Label

GFP+PURO

Fusion Tag

3×flag

Promoter

CMV

Resistance

Amplicin

gene description

The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the CXC chemokine receptor family. This family also includes CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, and CXCR7. This gene, which maps to the chemokine receptor gene cluster, is expressed in several T lymphocyte subsets and bone marrow stromal cells. The encoded protein and its exclusive ligand, chemokine ligand 16 (CCL16), are part of a signalling pathway that regulates T lymphocyte migration to various peripheral tissues (the liver, spleen red pulp, intestine, lungs, and skin) and promotes cell-cell interaction with dendritic cells and fibroblastic reticular cells. CXCR6/CCL16 also controls the localization of resident memory T lymphocytes to different compartments of the lung and maintains airway resident memory T lymphocytes, which are an important first line of defense against respiratory pathogens. The encoded protein serves as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4. [provided by RefSeq, Aug 2020]

Maker

GFP+PURO

Regulation

overexpression