human DERL1 Lentivirus plasmid

Cat:pGMLP002287
If you purchase ORF/cDNA clone-Lentivirus plasmid, ORF vector will be delivered with P-ALV-B11 backbone together.
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Availability:3-7 business days

Description

Catalog ID

pGMLP002287

Gene Name

DERL1

Product Name

human DERL1 Lentivirus plasmid

Accession Number

NM_024295

Gene ID

79139

Species

human

Product Type

Lentivirus plasmid

Insert Length

756

Gene Alias

DER-1;DER1;derlin-1

Fluorescent Label

GFP+PURO

Fusion Tag

3×flag

Promoter

CMV

Resistance

Amplicin

gene description

The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimer’s disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

Maker

GFP+PURO

Regulation

overexpression