human DERL1 Lentivirus plasmid
Cat:pGMLP002287
If you purchase ORF/cDNA clone-Lentivirus plasmid, ORF vector will be delivered with P-ALV-B11 backbone together.
Availability:3-7 business days
Description
Catalog ID
pGMLP002287
Gene Name
DERL1
Product Name
human DERL1 Lentivirus plasmid
Accession Number
NM_024295
Gene ID
79139
Species
human
Product Type
Lentivirus plasmid
Insert Length
756
Gene Alias
DER-1;DER1;derlin-1
Fluorescent Label
GFP+PURO
Fusion Tag
3×flag
Promoter
CMV
Resistance
Amplicin
gene description
The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimer’s disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
Maker
GFP+PURO
Regulation
overexpression