It’s the GeneMedi’s summary page for Target/Biomarker Introduction of TYR. The page also collects GeneMedi’s different modalities and formats products for TYR in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi’s target-insight database-GM ITD database, the TYR target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Introcelluar Protein.
The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3′ half of this gene. [provided by RefSeq, Oct 2008]