Pre-made Ocrelizumab benchmark antibody ( Whole mAb, anti-MS4A1/CD20 therapeutic antibody, Anti-B1/Bp35/CVID5/FMC7/LEU-16/S7 Antibody) for drug discovery and mechanism of action (MOA) research

Cat:GMP-Bios-ab-389

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SKU GMP-Bios-ab-389 Category Tag

Product Details

Pre-Made Ocrelizumab biosimilar, Whole mAb, Anti-MS4A1/CD20 Antibody: Anti-B1/Bp35/CVID5/FMC7/LEU-16/S7 therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Ocrelizumab, sold under the brand name Ocrevus, is a pharmaceutical drug for the treatment of multiple sclerosis (MS). It is a humanized anti-CD20 monoclonal antibody.[3] It targets CD20 marker on B lymphocytes and hence is an immunosuppressive drug.[4] Ocrelizumab binds to an epitope that overlaps with the epitope to which rituximab binds.[4]

Products Name (INN Index)

Pre-Made Ocrelizumab biosimilar, Whole mAb, Anti-MS4A1/CD20 Antibody: Anti-B1/Bp35/CVID5/FMC7/LEU-16/S7 therapeutic antibody

INN Name

Ocrelizumab

Target

MS4A1

Format

Whole mAb

Derivation

Humanized

Species Reactivity

Human

CH1 Isotype

IgG1

VD LC

Kappa

Highest_Clin_Trial (Jan '20)

Approved

Est. Status

NFD

100% SI Structure

None

99% SI Structure

None

95-98% SI Structure

4k7p:YX

Year Proposed

2005

Companies

Biogen,Biogen Idec,Chugai Pharmaceutical,Genentech,Roche

Conditions Approved

Multiple sclerosis

Conditions Active

NA

Conditions Discontinued

Eye disorders,Haematological malignancies,Lupus nephritis,Rheumatoid arthritis,Systemic lupus erythematosus

Development Tech

NA

Previous Name

NA

Gm Offical Target Name

MS4A1

Package

, ,

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