Pre-made Istiratumab benchmark antibody ( Bispecific Mixed mAb and scFv, anti-IGF1R;ERBB3/Erbb-3 therapeutic antibody, Anti-IGFR/CD221/IGFIR/JTK13;FERLK/HER3/LCCS2/MDA-BF-1/VSCN1/c-c-erbB3/p180-ErbB3/p45-sErbB3/p85-sErbB3 Antibody) for drug discovery and mechanism of action (MOA) research

Cat:GMP-Bios-ab-282

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SKU GMP-Bios-ab-282 Category Tags ,

Product Details

Pre-Made Istiratumab biosimilar, Bispecific Mixed mAb and scFv, Anti-IGF1R;ERBB3/Erbb-3 Antibody: Anti-IGFR/CD221/IGFIR/JTK13;FERLK/HER3/LCCS2/MDA-BF-1/VSCN1/c-c-erbB3/p180-ErbB3/p45-sErbB3/p85-sErbB3 therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Istiratumab (MM-141) is an experimental monoclonal antibody for the treatment of cancer. It is a bispecific antibody targeting IGF-1R and ErbB3.

Products Name (INN Index)

Pre-Made Istiratumab biosimilar, Bispecific Mixed mAb and scFv, Anti-IGF1R;ERBB3/Erbb-3 Antibody: Anti-IGFR/CD221/IGFIR/JTK13;FERLK/HER3/LCCS2/MDA-BF-1/VSCN1/c-c-erbB3/p180-ErbB3/p45-sErbB3/p85-sErbB

INN Name

Istiratumab

Target

IGF1R,ERBB3

Format

Bispecific Mixed mAb and scFv

Derivation

Bispecific antibody

Species Reactivity

Human

CH1 Isotype

IgG1;na

VD LC

Kappa,Lambda

Highest_Clin_Trial (Jan '20)

Phase-II

Est. Status

Discontinued

100% SI Structure

None;None

99% SI Structure

None;None

95-98% SI Structure

None;None

Year Proposed

2017

Companies

Adimab,Merrimack Pharmaceuticals

Conditions Approved

NA

Conditions Active

NA

Conditions Discontinued

Ovarian cancer,Pancreatic cancer,Solid tumours

Development Tech

NA

Previous Name

NA

Gm Offical Target Name

IGF1R,ERBB3

Package

, ,

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