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Pre-made Domagrozumab benchmark antibody ( Whole mAb, anti-MSTN/GDF-8 therapeutic antibody, Anti-GDF8/MSLHP Antibody) for drug discovery and mechanism of action (MOA) research
Cat:GMP-Bios-ab-151
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Product Details
Pre-Made Domagrozumab biosimilar, Whole mAb, Anti-MSTN/GDF-8 Antibody: Anti-GDF8/MSLHP therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Domagrozumab (PF-06252616) (INN) is a humanized monoclonal antibody designed for the treatment of Duchenne muscular dystrophy.
| Products Name (INN Index) | Pre-Made Domagrozumab biosimilar, Whole mAb, Anti-MSTN/GDF-8 Antibody: Anti-GDF8/MSLHP therapeutic antibody |
|---|---|
| INN Name | Domagrozumab |
| Target | MSTN |
| Format | Whole mAb |
| Derivation | Humanized |
| Species Reactivity | Human |
| CH1 Isotype | IgG1 |
| VD LC | Kappa |
| Highest_Clin_Trial (Jan '20) | Phase-II |
| Est. Status | Discontinued |
| 100% SI Structure | None |
| 99% SI Structure | 5f3h:EF:GH:AB:CD |
| 95-98% SI Structure | None |
| Year Proposed | 2015 |
| Year Recommended | 2016 |
| Companies | Kennedy Krieger Institute,Pfizer |
| Conditions Approved | NA |
| Conditions Active | NA |
| Conditions Discontinued | Duchenne muscular dystrophy,Limb girdle muscular dystrophies |
| Development Tech | NA |
| Previous Name | NA |
| Gm Offical Target Name | MSTN |
| Package |
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