Pre-made Daratumumab benchmark antibody ( Whole mAb, anti-CD38 therapeutic antibody, Anti-ADPRC1/ADPRC 1 Antibody) for drug discovery and mechanism of action (MOA) research

Cat:GMP-Bios-ab-133

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SKU GMP-Bios-ab-133 Category Tag

Product Details

Pre-Made Daratumumab biosimilar, Whole mAb, Anti-CD38 Antibody: Anti-ADPRC1/ADPRC 1 therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Daratumumab, sold under the brand name Darzalex, is an anti-cancer medication. It binds to CD38, which is overexpressed in multiple myeloma cells. Daratumumab was originally developed by Genmab, but it is now being jointly developed by Genmab along with the Johnson & Johnson subsidiary Janssen Biotech, which acquired worldwide commercialization rights to the drug from Genmab.

Products Name (INN Index)

Pre-Made Daratumumab biosimilar, Whole mAb, Anti-CD38 Antibody: Anti-ADPRC1/ADPRC 1 therapeutic antibody

INN Name

Daratumumab

Target

CD38

Format

Whole mAb

Derivation

Human

Species Reactivity

Human

CH1 Isotype

IgG1

VD LC

Kappa

Highest_Clin_Trial (Jan '20)

Approved

Est. Status

Active

100% SI Structure

None

99% SI Structure

None

95-98% SI Structure

None

Year Proposed

2009

Conditions Approved

Multiple myeloma

Conditions Active

Amyloid light-chain amyloidosis,Acute myeloid leukaemia,Chronic lymphocytic leukaemia,Diffuse large B cell lymphoma,Follicular lymphoma,Mantle-cell lymphoma,Myelodysplastic syndromes,Precursor B-cell

Conditions Discontinued

Non-small cell lung cancer

Development Tech

Medarex HuMAb Mouse

Previous Name

NA

Gm Offical Target Name

CD38

Package

, ,

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