Pre-made Alemtuzumab benchmark antibody ( Whole mAb, anti-CD52 therapeutic antibody, Anti-HE5/CDW52/EDDM5 Antibody) for drug discovery and mechanism of action (MOA) research

Cat:GMP-Bios-ab-015

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SKU GMP-Bios-ab-015 Category Tag

Product Details

Pre-Made Alemtuzumab biosimilar, Whole mAb, Anti-CD52 Antibody: Anti-HE5/CDW52/EDDM5 therapeutic antibody is a biosimilar expressed by mammalian cell line as a benchmark reference therapeutic antibody for biological drug disovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Alemtuzumab, sold under the brand names Campath and Lemtrada among others, is a medication used to treat chronic lymphocytic leukemia (CLL) and multiple sclerosis. In CLL, it has been used as both a first line and second line treatment. In MS it is generally only recommended if other treatments have not worked. It is given by injection into a vein.

Products Name (INN Index)

Pre-Made Alemtuzumab biosimilar, Whole mAb, Anti-CD52 Antibody: Anti-HE5/CDW52/EDDM5 therapeutic antibody

INN Name

Alemtuzumab

Target

CD52

Format

Whole mAb

Derivation

Humanized

Species Reactivity

Human

CH1 Isotype

IgG1

VD LC

Kappa

Highest_Clin_Trial (Jan '20)

Approved

Est. Status

Active

100% SI Structure

1bey:HL/1ce1:HL

99% SI Structure

None

95-98% SI Structure

None

Year Proposed

2000

Companies

Bayer HealthCare Pharmaceuticals Inc.,Dana-Farber Cancer Institute,German CLL Study Group,Ohio State University Comprehensive Cancer Center,Sanofi,Sanofi Oncology,University of Cologne,University of

Conditions Approved

Chronic lymphocytic leukaemia,Multiple sclerosis

Conditions Active

Lymphoma,T-cell prolymphocytic leukaemia

Conditions Discontinued

Rheumatoid arthritis,Diffuse large B cell lymphoma,Graft-versus-host disease,Sezary syndrome,T-cell lymphoma

Development Tech

NA

Previous Name

NA

Gm Offical Target Name

CD52

Package

, ,

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