Biological coupling with engineered unnatural amino acids

SOCAIL MEDIA

In addition to thiomonoclonal antibody technology, the addition of non-standard amino acids (NCAA) provides another possibility for site-specific coupling. The technology uses amino acids with unique chemical structure, which can introduce linker payload complexes in a chemically selective manner. This technique requires the recombination of antibody sequences, using tRNA and aminoacyl tRNA synthetase (AARS) orthogonal to all endogenous tRNAs and synthetases in the host cell to bring NCAA into the protein in response to unassigned codons. Generally, NCAA is added to the medium during fermentation. The selection of unnatural amino acids is important because they may stimulate immunogenicity. The commonly used NCAA is an analog of natural amino acids with unique groups, such as ketones, azides, cyclopropenes or dienes.

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Pre-Made Anetumab biosimilar, Whole mAb ADC, Anti-MSLN Antibody: Anti-MPF/SMRP therapeutic antibody
Anetumab
NA
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Whole mAb ADC
Pre-Made Aprutumab biosimilar, Whole mAb ADC, Anti-FGFR2 Antibody: Anti-BBDS/BEK/BFR-1/CD332/CEK3/CFD1/ECT1/JWS/K-SAM/KGFR/TK14/TK25 therapeutic antibody
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Whole mAb ADC
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NA
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NA
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NA
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NA
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CD79B
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NA
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NA
STEAP1
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NA
CD70
Whole mAb ADC
Pre-Made Tabituximab Barzuxetan Biosimilar, Whole Mab Adc, Anti-Fzd10 Antibody: Anti-CD350/FZ-10/Fz10/FzE7/hFz10 therapeutic antibody Drug Conjugate
tabituximab barzuxetan
NA
FZD10
Whole mAb ADC
Pre-Made Tamrintamab Pamozirine Biosimilar, Whole Mab Adc, Anti-Dpep3 Antibody: Anti-MBD3 therapeutic antibody Drug Conjugate
tamrintamab pamozirine
NA
DPEP3
Whole mAb ADC
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