Recombinant 2019-nCoV(SARS-CoV-2) Spike Protein RBD S477N mutant (B.1.526 lineage; 20A.EU2 lineage)

Recombinant 2019-nCoV(SARS-CoV-2) Spike Protein RBD S477N mutant (B.1.526 lineage; 20A.EU2 lineage)
The world is in midst of the COVID-19 pandemic. Recently a new SARS-CoV-2 (2019nCOV)lineage (B.1.526) emerged in New York and spread rapidly. The New York variant B.1.526 lineage is characterised by six lineage-defining mutations in the spike protein, including D614G mutation and one at important residues in the receptor-binding domain (S477N or E484K)1.The combination of E484K or S477N with a D253G mutation of the B.1.526 lineage that might confer immune escape and the increased number of COVID-19 cases2.

Mutations of Spike protein in SARS-COV-2 (2019nCOV) B.1.526 lineage spread in New York
One spike mutation is at key residues in the RBD (S477N or E484K), two are in the N-terminal domain (T95I and D253G) and one is in loop 2 (A701V)1.

Spike Mutation in SARS-COV-2 (2019nCOV) B.1.526 lineage SP L5F
Spike-S1 Subunit
N Terminal T95I
D253G Important residues mutation
Spike-RBD S477N or E484K Important residues mutation
Spike-S1 Subunit D614G A popular mutation in different new SARS-CoV-2 lineage
Spike-S2 Subunit A701V
Recombinant 2019-nCoV(SARS-CoV-2) Spike Protein RBD S477N mutant (B.1.526 lineage; 20A.EU2 lineage)

The world is in midst of the COVID-19 pandemic. Recently a new SARS-CoV-2 (2019nCOV)lineage (B.1.526) emerged in New York and spread rapidly. The New York variant B.1.526 lineage is characterised by six lineage-defining mutations in the spike protein, including D614G mutation and one at important residues in the receptor-binding domain (S477N or E484K)1.The combination of E484K or S477N with a D253G mutation of the B.1.526 lineage that might confer immune escape and the increased number of COVID-19 cases2.

Mutations of Spike protein in SARS-COV-2 (2019nCOV) B.1.526 lineage spread in New York
One spike mutation is at key residues in the RBD (S477N or E484K), two are in the N-terminal domain (T95I and D253G) and one is in loop 2 (A701V)1.

Spike Mutation in SARS-COV-2 (2019nCOV) B.1.526 lineage SP L5F
Spike-S1 Subunit
N Terminal T95I
D253G Important residues mutation
Spike-RBD S477N or E484K Important residues mutation
Spike-S1 Subunit D614G A popular mutation in different new SARS-CoV-2 lineage
Spike-S2 Subunit A701V